MS37452
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MS37452 속성
- 끓는 점
- 628.8±55.0 °C(Predicted)
- 밀도
- 1.209±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
- 산도 계수 (pKa)
- -1.31±0.70(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
안전
MS37452 C화학적 특성, 용도, 생산
개요
Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression. MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 μM). At 250 μM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.용도
MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 and has been shown to derepress transcription of the polycomb repressive complex target gene.Biochem/physiol Actions
MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.MS37452 준비 용품 및 원자재
원자재
준비 용품
MS37452 공급 업체
글로벌( 44)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 |
China | 4121 | 55 | |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9709 | 58 |
Shanghai Changyan Chem & Tech Co., Ltd. | 021-021-20242659 18930833303 |
order@changyanchem.com | China | 5008 | 55 |
Beijing OKA biological technology co., LTD | 010-62971590 18548936886 |
3462612863@qq.com | China | 6912 | 58 |
DC Chemicals | 021-58447131 13564518121 |
sales@dcchemicals.com | China | 9414 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 |
chenjw@absin.cn | China | 24734 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |