Dihydrokawain

Dihydrokawain 구조식 이미지
카스 번호:
587-63-3
상품명:
Dihydrokawain
동의어(영문):
MARINDININ;DIHYDROKAVAIN;DIHYDROKAWAIN;dihydro-kawai;DIHYDROKAWAIN;DIHYDROKAVAIN(P);7,8-DIHYDROKAWAIN;7,8-Dihydrokavain;(S)-(+)-7,8-Dihydrokavain;Dihydrokavain (7,8-Dihydrokawain
CBNumber:
CB4314738
분자식:
C14H16O3
포뮬러 무게:
232.27
MOL 파일:
587-63-3.mol
MSDS 파일:
SDS

Dihydrokawain 속성

녹는점
58-60°
알파
D24 +31° (methanol)
끓는 점
314.44°C (rough estimate)
밀도
1.1649 (rough estimate)
굴절률
1.5557 (estimate)
저장 조건
2-8°C
용해도
DMF:25.0(Max Conc. mg/mL);107.62(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);107.62(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);21.52(Max Conc. mM)
optical activity
[α]/D 29±2°, c = 0.5 in methanol
BRN
15362
InChIKey
VOOYTQRREPYRIW-LBPRGKRZSA-N
LogP
1.950 (est)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
WGK 독일 3
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
1 0

Dihydrokawain C화학적 특성, 용도, 생산

화학적 성질

White-pale yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the rhizome of kava-kava (Piper methysticum G. Forst).

용도

(+)-(S)-Dihydrokavain is a kavalactone found in kava beverages consumed by South Pacific islanders. Furthermore, roots and extracts of the kava plant have been used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.

정의

ChEBI: Dihydrokavain is a member of 2-pyranones and an aromatic ether.

주요 응용

Dihydrokavain is one of the six major kavalactones found in the kava plant; appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.Used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.

제조 방법

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(+)-dihydrokavain (1a) is demonstrated for the first time by total synthesis from a chiral source. Its opposite enantiomer, (R)-(–)-dihydrokavain (1b), was also synthesized after inversion of the chiral center in a Mitsunobu reaction.
A Total Synthesis of (+)- and (–)-Dihydrokavain with a Sonochemical Blaise Reaction as the Key Step

Dihydrokawain 준비 용품 및 원자재

원자재

준비 용품


Dihydrokawain 공급 업체

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