Fmoc-Asn(Trt)-OH

Fmoc-Asn(Trt)-OH 구조식 이미지
카스 번호:
132388-59-1
상품명:
Fmoc-Asn(Trt)-OH
동의어(영문):
FMOC-ASN(TRT)-OH;FMOC-ASN(TRT);FMOC-L-ASN(TRT)-OH;L-Asn(Trt);FMoc-Asn(Tre);Fmoc-N-trityL;PKUMDL-YC-1205;FMOC-ASN(XAN)-OH;FMOC-L-ASN(TRITYL);FMOC-ASPARAGINE(TRT)
CBNumber:
CB4331632
분자식:
C38H32N2O5
포뮬러 무게:
596.67
MOL 파일:
132388-59-1.mol
MSDS 파일:
SDS

Fmoc-Asn(Trt)-OH 속성

녹는점
201-204 °C(lit.)
알파
-16 º (c=1, MeOH)
끓는 점
858.1±65.0 °C(Predicted)
밀도
1.271±0.06 g/cm3(Predicted)
굴절률
-19 ° (C=1, DMF)
저장 조건
2-8°C
용해도
<0.00005g/l
산도 계수 (pKa)
3.79±0.10(Predicted)
물리적 상태
powder to crystal
색상
흰색에서 거의 흰색
optical activity
[α]20/D 15.0±1°, c = 1% in methanol
BRN
4343823
InChIKey
KJYAFJQCGPUXJY-UUWRZZSWSA-N
SMILES
C(O)(=O)[C@H](CC(N)=O)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1
CAS 데이터베이스
132388-59-1(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 53
안전지침서 24/25-61
유엔번호(UN No.) UN 3077 9 / PGIII
WGK 독일 2
F 고인화성물질 3-10
HS 번호 2924 29 70
위험 등급 IRRITANT
독성 LD50 orally in Rabbit: > 2000 mg/kg
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P273 환경으로 배출하지 마시오.
P391 누출물을 모으시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
1
0 0

Fmoc-Asn(Trt)-OH C화학적 특성, 용도, 생산

개요

Fmoc-Asn(Trt)-OH prevents the possibility of the amide side chain from undergoing dehydration side reactions during activation, especially with carbodiimide reagents. Fmoc-Asn(Trt)-OH dissolves readily in all standard peptide synthesis reagents, while Fmoc-Asn-OH is only somewhat soluble in NMP or DMF. The trityl group is removed with TFA. This reaction is usually complete within 1 hour at room temperature, but is slower when the Asn(Trt) residue in at the N-terminal of the peptide. In these cases, the deprotection reaction should be extended to 2 hours.

화학적 성질

white crystal powde

용도

Fmoc-Asn(Trt)-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.

제조 방법

Synthesis of Fmoc-Asn(Trt)-OH:
Step 1: Crystallization to form N'-Trityl-L-asparagine crystals.
Step 2: Centrifugation to extract N'-Trityl-L-asparagine crystals.
Step 3: Washing to remove residual starting materials in the synthesis.
Step 4: Extraction to obtain N-Acetyl-L-asparagine.
Step 5: Centrifugation to extract N'-Trityl-L-asparagine.
Step 6: Drying to obtain the final product.
This synthesis method effectively removes residual synthetic materials such as trifluoroacetic acid, maleic anhydride, and epichlorohydrin, which are similar in chemical properties to N-Acetyl-L-asparagine, from the product during the production process. The purification method is simple and the product obtained has high purity.

Fmoc-Asn(Trt)-OH 준비 용품 및 원자재

원자재

준비 용품


Fmoc-Asn(Trt)-OH 공급 업체

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