스티그마스테롤
|
|
스티그마스테롤 속성
- 녹는점
- 165-167 °C (lit.)
- 끓는 점
- 472.07°C (rough estimate)
- 알파
- -50 º (c=2, CHCl3)
- 밀도
- 0.9639 (rough estimate)
- 굴절률
- 1.5000 (estimate)
- 저장 조건
- -20°C
- 용해도
- 클로로포름: 용해성50mg/ml
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 15.03±0.70(Predicted)
- 색상
- 하얀색
- 수용성
- 불용성
- 최대 파장(λmax)
- 226nm(MeOH)(lit.)
- Merck
- 14,8815
- BRN
- 2568182
- LogP
- 10.072 (est)
- CAS 데이터베이스
- 83-48-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-38-40-48/20/22-36/37/38-67-36/38-20-63 | ||
안전지침서 | 22-24/25-36/37-36-26 | ||
유엔번호(UN No.) | UN 1888 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | WJ2447500 | ||
HS 번호 | 29309070 | ||
유해 물질 데이터 | 83-48-7(Hazardous Substances Data) |
스티그마스테롤 C화학적 특성, 용도, 생산
개요
Stigmasterol is a natural plant sterol that can be isolated from certain seed oils and herbs, including those used for therapeutic purposes. Dietary consumption of phytosterols, including stigmasterol, may have beneficial health effects in adults, particularly against cancer and ulceration. Alternatively, phytosterols may contribute to inflammation and intestinal failure-화학적 성질
white powder용도
Stigmasterol has been used as a phytosterol compound to test its anti-proliferative property in breast cancer cell culture and its effect on liver X receptor-α (LXRA) activation. It may be used as an internal standard for the quantification of yeast cell wall sterols using gas chromatography–mass spectrometry (GC-MS) analysis, and in the preparation of lipid monolayers.정의
ChEBI: A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.일반 설명
Stigmasterol is a plant sterol that comprises an unsaturated bond between C22 and C23. It is found in foods like margarines and yogurts. Stigmasterol is synthesized from the mevalonate pathway and is present during development stages in plants.Purification Methods
Stigmasterol is best purified via the tetrabromide-acetate. The impure sterol (3g) is acetylated with Ac2O (60mL) by refluxing for 1.5hour. The mixture is cooled at 20o for 1hour, and the crude acetate is collected. The acetate (3g) in Et2O (30mL) is then treated with Br2/AcOH (38mL, from 5g Br2 in 100mL AcOH), and after cooling at 6o overnight, the tetrabromoacetate is filtered off and washed with Et2O. After six recrystallisations from CHCl3/MeOH the tetrabromoacetate has m 194-196o. This product (1g) in AcOH (12mL) and Zn dust (1g) is refluxed for 1.5hours, filtered hot, diluted with H2O (30mL) and extracted with Et2O. The extract is washed with dilute aqueous sodium sulfite, then H2O, the extract is dried (Na2SO4) and the stigmasterol acetate (~550mg) is recrystallised (4x) from EtOH and twice from MeOH/CHCl3 (2:1) to give the acetate with m 139-148o. This acetate (400mg) is hydrolysed in boiling 10% alcoholic KOH (1mL) for 1hour. Then H2O (30mL) is added and the mixture is extracted with Et2O. The extract is washed with aqueous Na2CO3, then H2O, the solvent is distilled off and the residue is recrystallised (3x) from 95% EtOH to give ~110mg of pure stigmasterol. It is dried in a vacuum over P2O5 for 3hours at 90o. The purity is checked by NMR. The acetate crystallises from MeOH with m 145o, [] D 25 -56o (c 2, CHCl3). [Byerrum & Ball Biochemical Preparations 7 86 1959, Thornton et al. J Am Chem Soc 62 2006 1940, Colin et al. Anal Chem 51 1661 1979, Beilstein 6 IV 4170.]스티그마스테롤 준비 용품 및 원자재
원자재
준비 용품
스티그마스테롤 공급 업체
글로벌( 466)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2990 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
스티그마스테롤 관련 검색:
콜레스테롤 하이드록시 스테로이드 스티그마스테롤
(6E,22E)-(3R)-9,10-secoergosta-5(10),6,8,22-tetraen-3-ol
Tea polyphenol
PEPPERMINT
Dehydroandrographolide
Astaxanthin
Fattyacids:conjugated,synthetic
Vitamin K1
Phytol
Cimicifuga
DELTA7-STIGMASTEROL
Stigmasterol, 22,23-dihydro-
STIGMASTEROL ACETATE
7-Dehydrosigmasterol
7-ALPHA-HYDROXY-BETA-STIGMASTEROL
7-BETA-HYDROXY-BETA-STIGMASTEROL