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Carnosic acid

Carnosic acid 구조식 이미지
카스 번호:
3650-09-7
상품명:
Carnosic acid
동의어(영문):
salvin;CARNOSIC ACID;CARNOSOLIC ACID;CARNOSIC ACID(P);CARNOSIC ACID(RG);Carnosic acid, >=95%;Deoxypicrosalvinic acid;Carnosic Acid (Synthetic);Carnosic Acid, Free Acid, >99%;Carnosic acid from Rosmarinus officinalis
CBNumber:
CB4367749
분자식:
C20H28O4
포뮬러 무게:
332.43
MOL 파일:
3650-09-7.mol

Carnosic acid 속성

녹는점
190°C(lit.)
저장 조건
−20°C
물리적 상태
powder
색상
yellow
BRN
2707918
InChIKey
QRYRORQUOLYVBU-VBKZILBWSA-N
CAS 데이터베이스
3650-09-7(CAS DataBase Reference)

안전

안전지침서 22-24/25
WGK 독일 3
HS 번호 29182900

Carnosic acid C화학적 특성, 용도, 생산

화학적 성질

Yellow powder

정의

ChEBI: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from Rosmarinus officinalis and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.

Anticancer Research

Carnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.
The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).

Carnosic acid 준비 용품 및 원자재

원자재

준비 용품


Carnosic acid 공급 업체

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