ChemicalBook >제품 카탈로그 >생화학 공학>한약>터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸-

터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸-

터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- 구조식 이미지

카스 번호:: 115-37-7

한글명:: 터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸-

동의어(한글):: 터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸-

상품명:: THEBAINE

동의어(영문):: Tebain;C06173;Thebain;THEBAINE;Thenaine;p-Morphine;(-)-thebain;PARAMORPHINE;thebaine (90%);Thebaine (CRM)

CBNumber:: CB4404547

분자식:: C19H21NO3

포뮬러 무게:: 311.37

MOL 파일:: 115-37-7.mol

속성

안전

용도

터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- 속성

녹는점: 183-186°C (dec.)

알파: D15 -219° (p = 2 in alc); D23 -230° (p = 5 in chloroform)

끓는 점: 451.42°C (rough estimate)

밀도: 1.3050

굴절률: 1.5000 (estimate)

저장 조건: Controlled Substance, -20°C Freezer

용해도: H₂O: 2.2 mg/mL, 약간 용해됨

산도 계수 (pKa): 6.05(at 15℃)

물리적 상태: 가루

수용성: <10mg/L(상온)

EPA: Morphinan, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-,(5.alpha.)- (115-37-7)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T+
위험 카페고리 넘버	26/27/28
안전지침서	22-36/37/39-45
유엔번호(UN No.)	UN 1544 6.1/PG 2
WGK 독일	3
RTECS 번호	QD2975000
위험 등급	6.1(b)
포장분류	III

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험		P264, P270, P301+P310, P321, P330,P405, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310	삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P321	(…) 처치를 하시오.
P330	입을 씻어내시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
4		0

터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- C화학적 특성, 용도, 생산

개요

The naturally occurring opiate alkaloid thebaine is present in high concentrations in poppy straw; lower concentrations of the co deine alkaloid are present.

화학적 성질

Tan Solid

용도

Thebaine is present in opium at 0.3–1.5%.It is extracted from opium or from latex ofthe plant Papaver bracteatum, in which it ispresent at up to 26%. It is used to producecodeine.

위험도

Toxic by ingestion, may induce addiction.

건강위험

Although thebaine has a morphine- orcodeine-like structure, its pharmacologyaction is somewhat different. It is a convulsantpoison like strychnine, rather thana narcotic. High doses can cause ataxia andconvulsion
LD50 value, intraperitoneal (mice): 42 mg/kg
Thebaine is a habit-forming compound. Itis a controlled substance (opiate) listed underU.S. Code of Federal Regulations (Title 21Part 1308.12, 1985).

색상 색인 번호

The naturally occurring opiate alkaloid thebaine is present in concentrated poppy straw, and in small concentrations in codeine alkaloid. It is used in the manufacture of other opiate pharmaceuticals, such as buprenorphine and morphine, and caused contact dermatitis in a laboratory worker at an opiates manufacturing pharmaceutical company, also sensitive to codeine.

Purification Methods

Crystallise Thebaine from Et2O or EtOH. Sublime it at 170-180o. The hydrochloride decomposes >182o (from MeOH/Et2O). [Beilstein 27 II 177, 27 III/IV 2271.] It is a NARCOTIC.

참고 문헌

Pelletier, Thiboumery., Annalen, 16,38 (1835)
Kane., ibid, 19, 9 (1836)
Anderson., ibid, 86, 184 (1853)
Howerd., Ber., 17,527 (1884)
Pschorr, Zeidler., ibid, 27,2961 (1894)
Freund, Michaels, Gobel., ibid, 30, 1357 (1897)
Knorr., ibid, 36, 3074 (1903)
Freund, Holthof., ibid, 37, 2780 (1904)
Pschorr, Pfaff, Herrschmann., ibid, 38, 3163 (1905)
Reichard., Pharm. Zeit., 47,623 (1906)
Hildebrandt., Arch. expo Path. Pharm., 65,54 (1911)
Kruger, Eddy, Sumwalt., Suppl. No. 165, Public Health Reports, Washington (1943)
Flieschhacker, Pasal, Vieboeck., Monatsh., 99, 300 (1968)
Eppenberger, Warren, Repoport., Helv. Chim. Acta, 51,381 (1968)

터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- 준비 용품 및 원자재

원자재

CODEINONE Morphinan, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-5-(trimethylsilyl)-, (5β)- Morphinan, 7,8-didehydro-4,5-epoxy-3,6,6-trimethoxy-17-methyl-, (5α)- (5alpha)-6,7-didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan 하이드로코돈 6-O-METHYLCODEINE 오소 포름산 메틸 코데인

준비 용품

17-Northebaine HYDROCODONE BITARTRATE RELATED COMPOUND A CII (70 MG) (MORPHINAN-6-ONE, 4-HYDROXY-3-METHOXY-17-METHYL) (4aS,7aR)-3,4,6,7,7a,8-Hexahydro-12-hydroxy-11-methoxy-7-methyldibenz[d,f]indol-2(5H)-one (5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol Naltrexone 3-Methyl Ether 옥시코돈하이드로클로라이드

터바인;모르피난,6,7,8,14-테트라데하이드로-4,5-알파-에폭시-3,6-다이메톡시-17-메틸- 관련 검색:

오르토-삼차뷰틸페놀 2-(2-히드록시에톡시)페놀 3-ISOPROPYLCATECHOL 1,5-HEXADIEN-3-OL 2-(1,1-DIMETHYLPROPYL)PHENOL 4-Piperidineethanol 3-METHOXYPHENETHYL ALCOHOL (R)-4-AMINO-2-METHYL-1-BUTANOL 1-METHOXY-1,3-BUTADIENE (R)-(-)-1-Methyl-3-phenylpropylamine 3-ISOPROPYLPHENOL THEBAINE 4,4-dimethylpiperidine Drotebanol THEBAINONE ISOTHEBAINE OPIUM 3-(3-METHOXY-PHENYL)-PROPYLAMINE