PENTAGASTRIN
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PENTAGASTRIN 속성
- 녹는점
- 229-230° (dec)
- 알파
- D22 -28.8 ±0.5° (DMF)
- 끓는 점
- 1196.6±65.0 °C(Predicted)
- 밀도
- 1.303±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- 물에 거의 녹지 않습니다. 5M 암모니아와 디메틸포름아미드에 용해됩니다. 에탄올(96%)에 약간 용해됩니다.
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.19±0.10(Predicted)
- 색상
- White to off-white
- 시퀀스
- N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
- InChIKey
- NEYNJQRKHLUJRU-DZUOILHNSA-N
안전
- 위험 및 안전 성명
위험품 표기 | T | ||
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위험 카페고리 넘버 | 61-36/38-20/21 | ||
안전지침서 | 53-45-36/37/39-22 | ||
WGK 독일 | 1 | ||
RTECS 번호 | AY2970000 | ||
유해 물질 데이터 | 5534-95-2(Hazardous Substances Data) |
PENTAGASTRIN C화학적 특성, 용도, 생산
개요
Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.화학적 성질
A white or almost white powder.용도
Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.일반 설명
Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.
PENTAGASTRIN 준비 용품 및 원자재
원자재
준비 용품
PENTAGASTRIN 공급 업체
글로벌( 174)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10991 | 58 |
Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 |
mike@ge-tian.com | China | 269 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9357 | 55 |
Rixing Chemical CO.,LTD | +86-13237129059 -13237129059 |
sales@rixingchemi.com | CHINA | 229 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 |
sales04@yibaibiotech.com | CHINA | 419 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 8132 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
PENTAGASTRIN 관련 검색:
Terlipressin acetate
Lypressin
Ornipressin
ARGIPRESSIN ACETATE
Sucralfate
PENTAGASTRIN
tert-Butyl 3-(methylamino)propylcarbamate
N-Boc-1,3-propanediamine
MET-BETA-ALA
GASTRIN (14-17) (HUMAN)
Carbamic acid, [3-(propylamino)propyl]-, 1,1-dimethylethyl ester (9CI)
PENTAGASTRIN BP STANDARD(CRM STANDARD)
rat gastrin C-terminal pentagastrin
(ortho-nitrophenyl)sulfenyl pentagastrin
cholecystokinin 5-pentagastrin
PENTAGASTRIN BP(CRM STANDARD)
Pentagastrin, blocked
PENTAGASTRIN, [3H]