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Calcipotriene

Calcipotriene 구조식 이미지
카스 번호:
112965-21-6
상품명:
Calcipotriene
동의어(영문):
mc903;dovonex;Daivonex;Daivobet;Calciptriol;Calcipotriene;Calcipotriene-d4;CALCIPOTRIOL - EP;5z,7e,22e,24s)--bet;Calcipotriol hydrate
CBNumber:
CB4412713
분자식:
C27H40O3
포뮬러 무게:
412.6
MOL 파일:
112965-21-6.mol

Calcipotriene 속성

녹는점
166-168°C
끓는 점
582.0±50.0 °C(Predicted)
밀도
1.12±0.1 g/cm3(Predicted)
저장 조건
Desiccate at -20°C
용해도
DMSO: soluble15mg/mL, clear
산도 계수 (pKa)
14.29±0.20(Predicted)
물리적 상태
powder
InChIKey
LWQQLNNNIPYSNX-HCHVWAPNSA-N
CAS 데이터베이스
112965-21-6(CAS DataBase Reference)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26
유엔번호(UN No.) UN 2811 6.1 / PGIII
WGK 독일 3
HS 번호 2906195000

Calcipotriene MSDS


Calcipotriene

Calcipotriene C화학적 특성, 용도, 생산

개요

Calcipotriol is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, producing an elevation in cell differentiation and a reduction in cell proliferation. Although its efficacy is comparable to calcitriol, calcipotriol exhibits at least 100 times less effect on calcium metabolism in rats.

화학적 성질

White Crystalline Solid

Originator

Leo Denmark (Denmark)

용도

An antipsoriatic. A vitamin D3 analogue with low calcemic activity

용도

antipsoriatic;viamin D receptor (VDR) affinity

용도

A labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.

Indications

Calcipotriene (Dovonex), a synthetic vitamin D3 derivative, is indicated for the treatment of moderate plaque psoriasis. Its mechanism of action is unknown, although it competes for calcitriol receptors on keratinocytes and normalizes differentiation. It also has a variety of immunomodulatory effects in the skin. Although the drug can cause local irritation, the most serious toxicities are hypercalciuria and hypercalcemia, which are usually reversible.

상표명

Dovonex (Leo);Daivonex.

생물학적 활성

Vitamin D 3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Pharmacology

Calcipotriene (Dovonex) enhances the effectiveness of ultraviolet B (UVB) but also increases photosensitivity in UVB-treated patients. Ultraviolet light, 6% salicylic acid, 12% lactic acid, hydrocortisone valerate 0.2% ointment, and tazarotene (Tazorac) gel degrade calcipotriene (Dovonex). Halobetasol ointment and 5% tar gel are compatible with Calcipotriene (Dovonex). A British study found calcipotriene (Dovonex) to be safe and effective in a pediatric population over the age of 3, although it is not approved by the FDA.

Calcipotriene 준비 용품 및 원자재

원자재

준비 용품


Calcipotriene 공급 업체

글로벌( 145)공급 업체
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Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3050 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
QQ:800182836 stella@zetchem.com CHINA 2886 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58

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