Bupivacaine
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Bupivacaine 속성
- 녹는점
- 107.5-108°
- 끓는 점
- 430.65°C (rough estimate)
- 밀도
- 1.0238 (rough estimate)
- 굴절률
- 1.5700 (estimate)
- 산도 계수 (pKa)
- 8.09; also reported as 8.17(at 25℃)
- 수용성
- 101.5mg/L(25℃)
- InChI
- InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
- InChIKey
- LEBVLXFERQHONN-UHFFFAOYSA-N
- SMILES
- C1(CCCCN1CCCC)C(=O)NC1C(C)=CC=CC=1C
- CAS 데이터베이스
- 2180-92-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+ | ||
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위험 카페고리 넘버 | 26/27/28-38-41 | ||
안전지침서 | 22-26-36/37/39-45 | ||
유엔번호(UN No.) | 2811 |
그림문자(GHS): | |||||||||||||||||||||||||||||||||||||||||||||||||||
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신호 어: | Danger | ||||||||||||||||||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Bupivacaine C화학적 특성, 용도, 생산
용도
Like lidocaine and mepivacaine, bupivacaine is used in infiltration, spinal, and epidural anesthesia in blocking nerve transmission. Its most distinctive property is its long-lasting action. It is used for surgical intervention in urology and in lower thoracic surgery from 3 to 5 h in length, and in abdominal surgery lasting from 45 to 60 min. It is used to block the trifacial nerve, the sacral and brachial plexuses, in resetting dislocations, in epidural anesthesia, and during Cesarian sections.일반 설명
Bupivacaine was synthesized simultaneously with mepivacainein 1957 but was at first overlooked because of the increasedtoxicity compared with mepivacaine. When themethyl on the cyclic amine of mepivacaine is exchanged fora butyl group the lipophilicity, potency and the duration ofaction all increase. Literature reports of cardiovascular toxicity,including severe hypotension and bradycardia, areabundant in the literature.91 Bupivacaine is highly bound toplasma proteins (95%), and thus the free concentration mayremain low until all of the protein binding sites are occupied.After that point, the plasma levels of bupivacaine rise rapidlyand patients may progress to overt cardiac toxicity withoutever showing signs of CNS toxicity. The cardiotoxicity ofbupivacaine is a result of its affinity to cardiac tissues and itsability to depress electrical conduction and predispose theheart to reentry types of arrhythmias. The cardiotoxicity ofbupivacaine was found to be significantly more prominentwith the “R” isomer, or the racemic mixture, thus the “S”stereoisomer is now on the market as levobupivacaine.Mechanism of action
Bupivacaine is a local anaesthetic containing a chiral centre and adopts dextro and laevo forms. The enantiopure l form is less cardio- and neurotoxic and has an equivalent potency to the racemic mixture; therefore levobupivacaine is often preferred to reduce the potential for toxicity. Stereoselectivity describes the differences in response at a given receptor for the different enantiomers (such as the response discussed for S(+) ketamine). The opioid and NMDA receptors also exhibit stereoselectivity.Pharmacology
Bupivacaine is a chiral compound used clinically for 50 years, with a slower onset, greater potency and longer duration of action than lidocaine. Initial benefits of bupivacaine were sensory–motor separation and minimal tachyphylaxis, unlike repeated doses of lidocaine. However, it has greater potential for cardiac toxicity, related to its avid binding to and slow dissociation from cardiac N a+ channels. Inadvertent intravenous administration may result in systemic toxicity (see later), and it is contraindicated for intravenous regional anaesthesia.Bupivacaine is commonly used for epidural administration in obstetrics and postoperative pain management. A hyperbaric preparation containing 80 mg ml-1 glucose is available for spinal anaesthesia.
부작용
Common side effects of bupivacaine include:weakness, long-lasting numbness or tingling;
feeling restless or drowsy;
tremors;
headache, blurred vision;
fast or slow heartbeats;
breathing problems;
chills or shivering;
back pain;
nausea, vomiting.
Bupivacaine 준비 용품 및 원자재
원자재
Ethyl 2-bromo-6-chlorohexanoate
핵산산
모노부틸아민
Ethyl pipecolinate
2,6-다이메틸아닐린
말론산 디에틸
니트로실 클로라이드
개미산
브롬화부틸
아연
4-Bromo-2,6-dimethylaniline
준비 용품
Bupivacaine 공급 업체
글로벌( 265)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 |
info@pharmachemm.com | China | 246 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 |
sales@chembj.net | China | 269 | 58 |
Shanghai Aosiris new Material Technology Co., LTD | +8615139564871 |
wrjmoon2000@163.com | China | 354 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 305 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 |
xinshengkeji@xsmaterial.com | China | 1100 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 524 | 58 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Bupivacaine 관련 검색:
다이부틸푸탈레이트 N,N-다이메틸폼아마이드 부틸 올레인산염 아세트산부틸 시할로폽부틸 브푸로페진 부틸글리콜 피페리딘
Levobupivacaine
Mepivacaine
Articaine
Des-butyl Bupivacaine (Bupivacaine metabolite)
Bupivacaine Related Compound A
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride,BUPIVACAINE HYDROCHLORIDE
Levobupivacaine hydrochloride
Bupivacaine Related Compound B
D-(+)-Bupivacaine,d-Bupivacaine,(R)-(+)-Bupivacaine,(R)-(+)-BUPIVACAINE HCL
CARBOXAMIDE