6-HYDROXYMELATONIN
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6-HYDROXYMELATONIN 속성
- 녹는점
- 172-175°C
- 끓는 점
- 564.7±50.0 °C(Predicted)
- 밀도
- 1.266±0.06 g/cm3(Predicted)
- 저장 조건
- Refrigerator
- 용해도
- 알코올: 용해 가능
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 10.12±0.40(Predicted)
- 색상
- 흰색에서 베이지색
- InChIKey
- OMYMRCXOJJZYKE-UHFFFAOYSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,N | ||
---|---|---|---|
위험 카페고리 넘버 | 22-40-51/53-20 | ||
안전지침서 | 36/37-60 | ||
WGK 독일 | 3 | ||
RTECS 번호 | AC3607000 |
6-HYDROXYMELATONIN C화학적 특성, 용도, 생산
개요
6-hydroxy Melatonin is an active metabolite of melatonin . It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 μM). 6-hydroxy Melatonin (10 and 100 μM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis. It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.화학적 성질
Off-White to Pale Beige Solid용도
6-Hydroxymelatonin has been used as a melatonin derivative to test its protective effects in ultra violet B (UVB)-induced oxidative stress melanocytes and keratinocytes.정의
ChEBI: A member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6.일반 설명
6-Hydroxymelatonin (6-OHM) is a melatonin metabolite. It is produced in the liver by the action of cytochrome P450 enzyme as well as by photodegradation of melatonin. In the central nervous system, it exists as a sulfated form. 6-OHM is a partial melatonin receptor MT2 agonist.6-HYDROXYMELATONIN 준비 용품 및 원자재
원자재
준비 용품
6-HYDROXYMELATONIN 공급 업체
글로벌( 69)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hebei Duling International Trade Co. LTD | +8618032673083 |
sales05@hbduling.cn | China | 15747 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 |
cherry@crovellbio.com | China | 18458 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11681 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 |
info@chemextension.com | China | 42057 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |