Irbesartan
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Irbesartan 속성
- 녹는점
- 180-181°C
- 끓는 점
- 648.6±65.0 °C(Predicted)
- 밀도
- 1.30±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: >25mg/mL
- 산도 계수 (pKa)
- 4.16±0.10(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- Merck
- 14,5083
- BCS Class
- 2
- CAS 데이터베이스
- 138402-11-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22 | ||
안전지침서 | 26-24/25 | ||
WGK 독일 | 3 | ||
RTECS 번호 | HM2950270 | ||
HS 번호 | 29332900 | ||
유해 물질 데이터 | 138402-11-6(Hazardous Substances Data) |
Irbesartan MSDS
3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one
Irbesartan C화학적 특성, 용도, 생산
개요
Avapro was launched in Germany, the UK and the US for hypertension. It can be prepared in six steps starting with cyclopentanone or in three steps from 1- aminocyclopentanecarboxylic acid ethyl ester and pentanimidic ethyl ester. Avapro is an angiotensin Ⅱ receptor antagonist that is non-competitive and selective for AT, subtypes and has no AT2 activity at postsynaptic receptors compared to presynatpic. It has no affinity for various non angiotensin Ⅱ receptor types in binding, no interaction with calcium channels or antiports, and no affinity for α1- and α2--adrenoreceptors, serotonergic receptors, muscarinic m1 and m2 or other receptors. It is as potent as saralasin but with no agonist activity and is 10 times more potent than DuP753 in rats. It is similar in efficacy to enalapril (in those with severe hypertension) and atenolol, while more effective than losartan for mild to moderate hypertension.화학적 성질
Crystalline Solid용도
For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of conges정의
ChEBI: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.일반 설명
Irbesartan, 2-butyl-3-[[29-(1H-tetrazol-5-yl)[1,19-biphenyl]-4-yl]methyl]1,3-diazaspiro[4,4]non-1en-4-one (Avapro), like losartan, possesses the acidic tetrazolesystem, which most likely plays a role, similar to the acidicgroups of angiotensin II, in binding to the angiotensin II receptor.In addition, the biphenyl system that serves to separatethe tetrazole from the aliphatic nitrogen is still present.A major difference in this agent is that it does not possessthe acidic side chain. Even so, irbesartan has good affinityfor the angiotensin II receptor because of hydrogen bondingwith the carbonyl moiety of the amide system. Also, thisparticular agent does not require metabolic activation ascandesartan does.Irbesartan 준비 용품 및 원자재
원자재
3-METHOXYPROPIONIC ACID
Triethyl orthobutyrate
소디움 아지이드
ORTHO-N-VALERIC ACID TRIETHYL ESTER
플루오렌
1H-테트라졸
벤질아민
펜타노일 클로라이드
사이클로펜타논
트리틸클로라이드
Cycloleucine
사이안화 나트륨
ETHYL PENTANIMIDATE
Tributyltin azide
트리에틸아민
4-Bromomethyl-2-cyanobiphenyl
옥살산
준비 용품
Irbesartan 공급 업체
글로벌( 781)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12457 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Irbesartan 관련 검색:
4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-(1,1'-biphenyl)-2-carbonitrile
2-Butyl-4-spirocyclopentane-2-imidazolin-5-one hydrochloride
Irbesartan Related Compound A
Trityl Irbesartan
Irbesartan
2-n-butyl-l,3-diazaspiro[4,4]non-l-ene-4-one(for Irbesartan)
Irbesartan N--D-Glucuronide
IRBESARTAN-D4
IRBESARTAN-D3
2-butyl-1,3-biazaspiro[4,4]-non-1-ene-4-one hydrochloride (intermediate of Irbesartan)
Irbesartan Tablets
Irbesartan13
IRBESARTAN (GMP)
intermediate of irbesartan
4-bromomethyl-2-(1-triphenylmethyltetrazole-5-yl)biphenyl (intermediate of Irbesartan)
Irbesartan2-(4-AminomethylPhenyl)Benzonitrile
IRBESARTAN
Irbesartan, Crude