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Irbesartan

Irbesartan 구조식 이미지
카스 번호:
138402-11-6
상품명:
Irbesartan
동의어(영문):
AVAPRO;APROVEL;SR-47436;Irbesarta;Irbesatan;BMS-186295;IRBESARTAN;Lrbesartan;Irbersartan;Irbesartan(Avapro)
CBNumber:
CB4454663
분자식:
C25H28N6O
포뮬러 무게:
428.53
MOL 파일:
138402-11-6.mol

Irbesartan 속성

녹는점
180-181°C
저장 조건
-20°C Freezer
용해도
DMSO: >25mg/mL
물리적 상태
powder
색상
white to off-white
Merck
14,5083
CAS 데이터베이스
138402-11-6(CAS DataBase Reference)

안전

위험품 표기 Xn
위험 카페고리 넘버 22
안전지침서 26-24/25
WGK 독일 3
RTECS 번호 HM2950270
HS 번호 29332900

Irbesartan C화학적 특성, 용도, 생산

개요

Avapro was launched in Germany, the UK and the US for hypertension. It can be prepared in six steps starting with cyclopentanone or in three steps from 1- aminocyclopentanecarboxylic acid ethyl ester and pentanimidic ethyl ester. Avapro is an angiotensin Ⅱ receptor antagonist that is non-competitive and selective for AT, subtypes and has no AT2 activity at postsynaptic receptors compared to presynatpic. It has no affinity for various non angiotensin Ⅱ receptor types in binding, no interaction with calcium channels or antiports, and no affinity for α1- and α2--adrenoreceptors, serotonergic receptors, muscarinic m1 and m2 or other receptors. It is as potent as saralasin but with no agonist activity and is 10 times more potent than DuP753 in rats. It is similar in efficacy to enalapril (in those with severe hypertension) and atenolol, while more effective than losartan for mild to moderate hypertension.

화학적 성질

Crystalline Solid

Originator

Sanofi (France)

용도

An angiotensin II type 1 (AII1)-receptor antagonist

용도

antidepressant

용도

For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of conges

정의

ChEBI: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

상표명

Avapro (Sanofi Aventis);Aprovel/Avapro.

일반 설명

Irbesartan, 2-butyl-3-[[29-(1H-tetrazol-5-yl)[1,19-biphenyl]-4-yl]methyl]1,3-diazaspiro[4,4]non-1en-4-one (Avapro), like losartan, possesses the acidic tetrazolesystem, which most likely plays a role, similar to the acidicgroups of angiotensin II, in binding to the angiotensin II receptor.In addition, the biphenyl system that serves to separatethe tetrazole from the aliphatic nitrogen is still present.A major difference in this agent is that it does not possessthe acidic side chain. Even so, irbesartan has good affinityfor the angiotensin II receptor because of hydrogen bondingwith the carbonyl moiety of the amide system. Also, thisparticular agent does not require metabolic activation ascandesartan does.

Veterinary Drugs and Treatments

Although experience in veterinary medicine is minimal irbesartan may be useful in treating canine hypertension associated with renal insufficiency. It may be effective in treating heart failure when dogs are unable to tolerate ACE inhibitors, but documentation for this use is lacking. One study, using very high irbesartan dosages (60 mg/kg PO twice daily) in dogs with subacute mitral regurgitation, demonstrated no improvement in left ventricular function or prevention of left ventricular remodeling (Perry, Wei et al. 2002).

Irbesartan 준비 용품 및 원자재

원자재

준비 용품


Irbesartan 공급 업체

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Capot Chemical Co.,Ltd.
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Henan DaKen Chemical CO.,LTD.
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58

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