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메나디온

메나디온
메나디온 구조식 이미지
카스 번호:
58-27-5
한글명:
메나디온
동의어(한글):
비타민K3;메나디온;2-메틸-1,4-나프탈렌디온;메나다이온
상품명:
Menadione
동의어(영문):
VK3;Kipca;Juva-K;Kanone;Karcon;Kareon;Kaykot;Koaxin;Synkay;Aquakay
CBNumber:
CB4494726
분자식:
C11H8O2
포뮬러 무게:
172.18
MOL 파일:
58-27-5.mol

메나디온 속성

녹는점
105-107 °C(lit.)
끓는 점
262.49°C (rough estimate)
밀도
1.1153 (rough estimate)
굴절률
1.5500 (estimate)
저장 조건
Store at RT.
용해도
oil: soluble
물리적 상태
crystalline
색상
yellow
수용성
INSOLUBLE
감도
Light Sensitive
Merck
14,5831
BRN
1908453
안정성
Stable. May be light sensitive. Incompatible with strong oxidizing agents.
InChIKey
MJVAVZPDRWSRRC-UHFFFAOYSA-N
CAS 데이터베이스
58-27-5(CAS DataBase Reference)
NIST
Menadione(58-27-5)
EPA
Menadione (58-27-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36/37/38-43
안전지침서 26-36-37/39-24
WGK 독일 3
RTECS 번호 QL9100000
F 고인화성물질 8
TSCA Yes
위험 등급 IRRITANT
HS 번호 29147000
유해 물질 데이터 58-27-5(Hazardous Substances Data)
독성 LD50 orally in mice: ~0.5 g/kg (Molitor, Robinson)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

메나디온 C화학적 특성, 용도, 생산

화학적 성질

Bright yellow crystals

용도

Precursor to verious types of Vitamin K. Used as a micronutrient for livestock and pet foods.

용도

prothrombogenic agent

용도

antibacterial

용도

The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.

용도

vitamin K helps promote blood clotting and has been used medically to reduce the possibility of bruising after surgery. It is being incorporated into cosmetic preparations, particularly those used for treating dark circles. It could also be used in acne products, and there are studies underway on its efficacy for the treatment of spider veins.

용도

Menadione (Vitamin K) is a fat-soluble vitamin that is essential for blood clotting. It is destroyed by irradiation during processing but has no appreciable loss during storage. It occurs in spinach, cabbage, liver, and wheat bran.

Indications

Vitamin K activity is associated with several quinones, including phylloquinone (vitamin K1), menadione (vitamin K3), and a variety of menaquinones (vitamin K2). These quinones promote the synthesis of proteins that are involved in the coagulation of blood.These proteins include prothrombin, factor VII (proconvertin), factor IX (plasma thromboplastin). The vitamin K quinones are obtained from three major sources.Vitamin K is present in various plants, especially green vegetables. The menaquinones that possess vitamin K2 activity are synthesized by bacteria, particularly gram-positive organisms; the bacteria in the gut of animals produce useful quantities of this vitamin.Vitamin K3 is a chemically synthesized quinone that possesses the same activity as vitamin K1.

정의

ChEBI: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group.

상표명

Kappaxin (Sterling Winthrop); Kayquinone.

위험도

Irritant to skin and mucous membranes, especially the alcoholic solution.

Clinical Use

Vitamin K deficiency results in increased bleeding time. This hypoprothrombinemia may lead to hemorrhage from the gastrointestinal tract, urinary tract, and nasal mucosa. In normal, healthy adults, deficiency is rare. The two groups at greatest risk are newborn infants and patients receiving anticoagulant therapy; hypoprothrombinemia preexists in these two groups. Any disease that causes the malabsorption of fats may lead to deficiency. Inhibition of the growth of intestinal bacteria from extended antibiotic therapy will result in decreased vitamin K synthesis and possible deficiency.

부작용

Toxicity of vitamin K has not been well defined. Jaundice may occur in a newborn if large dosages of vitamin K are given to the mother before birth. Although kernicterus may result, this can be prevented by using vitamin K.

Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. Experimental teratogenic effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Recrystallise it from 95% EtOH, or MeOH after filtration. It forms bright yellow crystals which are decomposed by light. Its solubility in EtOH is 1.7% and in *C6H6 it is 10%. It IRRITATES mucous membranes and skin. [Fieser J Biol Chem 133 391 1940, Beilstein 7 IV 2430.]

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