NS 3694

NS 3694 C화학적 특성, 용도, 생산

개요

Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC₅₀ value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.

용도

NS3694 is a suppressor of the formation of apoptosome Apaf-1.

NS 3694 준비 용품 및 원자재

원자재

준비 용품

NS 3694 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
InvivoChem	13549236410	sales@invivochem.cn	China	6712	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

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