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OLOMOUCINE II

OLOMOUCINE II 구조식 이미지

카스 번호:: 500735-47-7

상품명:: OLOMOUCINE II

동의어(영문):: Nsc736738;Olomoucine II - CAS 500735-47-7 - Calbiochem;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-

CBNumber:: CB4504061

분자식:: C19H26N6O2

포뮬러 무게:: 370.45

MOL 파일:: 500735-47-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 11

OLOMOUCINE II 속성

끓는 점: 618.5±65.0 °C(Predicted)

밀도: 1.32

저장 조건: −20°C

용해도: 클로로포름: 50mg/mL, 가용성

물리적 상태: 가루

산도 계수 (pKa): 9.83±0.30(Predicted)

안전

안전지침서	22-24/25
WGK 독일	3

OLOMOUCINE II C화학적 특성, 용도, 생산

일반 설명

A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC₅₀ of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC₅₀ = 50 nM), Roscovitine (Cat. No. 557360; IC₅₀ = 450 nM), Bohemine (Cat. No. 203600; IC₅₀ = 1.1 μM) and Olomoucine (Cat. No. 495620; IC₅₀ = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC₅₀ = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

Biochem/physiol Actions

Cell permeable: yes

OLOMOUCINE II 준비 용품 및 원자재

원자재

준비 용품

OLOMOUCINE II 공급 업체

글로벌( 11)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
ChemeGen 中国	18818260767	sales@chemegen.com	China	6975	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

OLOMOUCINE II 관련 검색:

Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE AMINOPURVALANOL A SU 9516 NU6102 OLOMOUCINE