눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
1
2
0
3,5-디히드록시아니솔수화물 C화학적 특성, 용도, 생산
용도
5-Methoxyresorcinol was used in synthesis of isorobustin, substituted linear and angular benzofurocoumarins.
일반 설명
Kinetics of the aroxyl radical-scavenging action of 5-methoxyresorcinol has been investigated. The kinetics of reaction of 5,7-diisopropyl-tocopheroxyl radical (Toc) with 5-methoxyresorcinol has been measured by stopped-flow spectrophotometer.
Synthesis
Anhydrous phloroglucinol (25g,0.198 mole) is dissolved in absolutemethyl alcohol (100 ml) and the solution cooled to 18°.Dry hydrogenchloride gas is passed through the solution for 25 min at such a rate thatthe solution does not get saturated (approx. 200 bubbles/min).Themixture is then refluxed for 15 min，cooled immediately to 18° and dryhydrogen chloride gas passed again for25 min. The reaction mixture isallowed to stand for 12 hr and the solvent is removed by distillation invacuo.Great care is taken to remove as much of the solvent as possiblewithout applying any heat (preferably in rotatory evaporator).The residueis poured into water (500 ml) and extracted with ether (4 × 75 ml). The ether solution is dried (anhydrous sodium sulphate) and then distilled.The residual oily product is distilled in vacuo. A small quantity ofo-dimethyl phloroglucinol (5g,16.4 %) distils over first at 185-190°/25 mm and then o-monomethyl phloroglucinol (15g,54.2%) distils over at210° as a viscous oil. The viscous oil solidifies on standing for 2-3 days.M.p.78°.The yields are not consistent and vary according to the extent ofsaturation.
