N-[(부틸아미노)카보닐]-4-메틸벤젠설폰아마이드
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N-[(부틸아미노)카보닐]-4-메틸벤젠설폰아마이드 속성
- 녹는점
- 128-130°C
- 밀도
- 1.2450
- 굴절률
- 1.6360 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 클로로포름에 용해됩니다.
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- pKa 5.32(H2O t = 37) (Uncertain)
- 색상
- 흰색에서 황백색까지
- 수용성
- 0.14g/L(25℃)
- Merck
- 14,9507
- BRN
- 1984428
- Specific Activity
- 50-60 mCi/mmol
- Concentration
- 0.1 mCi/ml
- Solvent
- Ethanol
- 안정성
- 안정적인. 타기 쉬운.
- CAS 데이터베이스
- 64-77-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21/22-40-43-36-11 | ||
안전지침서 | 26-36/37/39-36/37-16-24/25 | ||
WGK 독일 | 2 | ||
RTECS 번호 | YS4550000 | ||
TSCA | Yes | ||
HS 번호 | 29350090 | ||
유해 물질 데이터 | 64-77-7(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 2490mg/kg | ||
기존화학 물질 | KE-04198 |
N-[(부틸아미노)카보닐]-4-메틸벤젠설폰아마이드 C화학적 특성, 용도, 생산
화학적 성질
White or almost white, crystalline powder.용도
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.정의
ChEBI: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.일반 설명
Tolbutamide is N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide;or 1-butyl-3-(p-tolylsulfonyl)urea (Orinase,generic). Orinase Diagnostic was the sodium salt, which isfreely soluble in water for injection, but this product was discontinuedc. 2000.공기와 물의 반응
Insoluble in water.반응 프로필
TOLBUTAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLBUTAMIDE is incompatible with acids. .화재위험
Flash point data for TOLBUTAMIDE are not available. TOLBUTAMIDE is probably combustible.Mechanism of action
Tolbutamide is one of the most widely used antidiabetic agents. Its action is preferably connected with stimulatory action of β-cells in the pancreas, which results in intensive insulin secretion.Clinical Use
Tolbutamide should be used only when the diabetic patientis an adult or shows adult-onset diabetes, and the patientshould adhere to dietary restrictions.Safety Profile
Moderately toxic by ingestion and several other routes. A human teratogen. Human reproductive effects by ingestion and possibly other routes: stillbirth, developmental abnormalities of the cardlovascular (circulatory) system and urogenital system, and unspecified neonatal effects. Human systemic effects by ingestion: nausea or vomiting, hypoglycemia. Other experimental teratogenic and reproductive effects. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NO, and SOx.N-[(부틸아미노)카보닐]-4-메틸벤젠설폰아마이드 준비 용품 및 원자재
원자재
준비 용품
N-[(부틸아미노)카보닐]-4-메틸벤젠설폰아마이드 공급 업체
글로벌( 280)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15394 | 58 |
N-[(부틸아미노)카보닐]-4-메틸벤젠설폰아마이드 관련 검색:
알파-톨루엔설포닐 염화물 설파닐아미드
Repaglinide
CHLORPROPAMIDE
HYDROXY TOLBUTAMIDE
Glimepiride
Tolbutamide-d9
4-Carboxytolbutamide Methyl Ester
TOLAZAMIDE
Tolbutamide 4-Carboxy Ethyl Ester
Tolbutamide Impurity 5
tolbutamide sodium
HYDROXY TOLBUTAMIDE-D9
Tolbutamide-d9 Carboxylic Acid
Tetracaine-d6 Hydrochloride
Tolbutamide Carboxylic Acid
Tolbutamide, substrate for Cytochrome P450 2C9
[RING-U-14C]TOLBUTAMIDE