2-요오드아세트아미드
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2-요오드아세트아미드 속성
- 녹는점
- 92-95 °C(lit.)
- 끓는 점
- 297.1±23.0 °C(Predicted)
- 밀도
- 2.1103 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 물, 디메틸 포름아미드 및 에탄올에 용해됩니다. 메탄올에 약간 용해됩니다.
- 물리적 상태
- 수정 같은
- 산도 계수 (pKa)
- 15.16±0.40(Predicted)
- 색상
- 흰색에서 연한 노란색 또는 베이지색
- 수용성
- H2O: 20°C에서 0.5M, 투명, 무색
- 감도
- Light Sensitive
- BRN
- 1739080
- 안정성
- 안정적이지만 빛에 민감합니다. 강산화제, 강염기, 환원제, 산과 호환되지 않습니다.
- InChIKey
- PGLTVOMIXTUURA-UHFFFAOYSA-N
- CAS 데이터베이스
- 144-48-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 25-42/43-43-36/37/38-53 | ||
안전지침서 | 22-36/37-45-37/39-26-24 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | AC4200000 | ||
F 고인화성물질 | 8-10-21 | ||
TSCA | T | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29241900 | ||
기존화학 물질 | KE-21033 |
2-요오드아세트아미드 C화학적 특성, 용도, 생산
화학적 성질
White solid in amber, foil sealed microtubes. Soluble in hot water, easily soluble in ethanol.용도
2-Iodoacetamide is an alkylating reagent for cysteine residues in peptide sequencing. Its actions are similar to those of iodoacetate. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.주요 응용
Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation 2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.생물학적 활성
Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease.Synthesis
2-Iodoacetamide is synthesized by reacting chloroacetamide with sodium iodide. The chloroacetamide, anhydrous acetone, and anhydrous sodium iodide were refluxed on the bath for 15h. Cool to room temperature, filter out sodium chloride, recover acetone, pour into ice water of sodium bisulfate after a little cooling, and then neutralize to pH 6 with saturated sodium sulfate solution. Cool to crystallize and filter to obtain crude product. The crude product is recrystallized with water to obtain the finished product.Purification Methods
Crystallise it from water or CCl4. It is used for tagging proteins. [Gurd Methods Enzymol 25 424 1972, Beilstein 2 IV 536.]주의 사항
Store in a cool place. Light and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.2-요오드아세트아미드 준비 용품 및 원자재
원자재
준비 용품
2-요오드아세트아미드 공급 업체
글로벌( 377)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Xiamen Yunfan Biotech Co.,Ltd. | +8618050056030 |
yezhaobao@yfpharm.com | China | 27 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18629 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9355 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
2-요오드아세트아미드 관련 검색:
아세트아마이드 2-요오드아세트아미드 5-아이오도우라실 5-아이오도우리딘
Iodobenzene
Lead(II) iodide
Potassium iodide
Cuprous iodide
Zinc iodide
Cyclopropyl iodide
Sodium iodide
IODOCYCLOPENTANE
Cesium iodide
Lithium iodide
IODOANTIPYRINE
EDANS IODOACETAMIDE
BENZOPHENONE-4-IODOACETAMIDE
SULFO-N-SUCCINIMIDYL (N-IODOACETYL)AMINOBENZOATE