아이로페리돈
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아이로페리돈 속성
- 녹는점
- 118-120°C
- 끓는 점
- 593.7±50.0 °C(Predicted)
- 밀도
- 1.204±0.06 g/cm3(Predicted)
- 인화점
- 9℃
- 저장 조건
- -20°C
- 용해도
- DMSO: 용해성5mg/mL, 투명
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 8.43±0.20(Predicted)
- 색상
- 흰색에서 베이지색
- Merck
- 14,4900
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,T | ||
---|---|---|---|
위험 카페고리 넘버 | 11-23/24/25-39/23/24/25 | ||
안전지침서 | 16-36/37-45 | ||
유엔번호(UN No.) | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | ||
WGK 독일 | 1 | ||
RTECS 번호 | KM5777850 | ||
HS 번호 | 29349990 | ||
유해 물질 데이터 | 133454-47-4(Hazardous Substances Data) |
아이로페리돈 C화학적 특성, 용도, 생산
개요
Iloperidone is an atypical antipsychotic and adrenergic, dopamine, and serotonin (5-HT) receptor antagonist. It binds to several receptors, including the α1-adrenergic receptor (α1-AR), α2-AR, and dopamine D2 receptor (Kis = 0.31, 3, and 3.3 nM, respectively), as well as the 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors (Kis = 33, 15, 0.2, and 14 nM, respectively) in radioligand binding assays using human post-mortem brain tissue. Iloperidone also binds to human D1, D3, D4, D5, and rat 5-HT2 receptors (Kis = 216, 7.1, 25, 319, and 3.1 nM, respectively, in CHO cells) and the histamine H1 receptor (Ki = 12.3 nM in human post-mortem brain tissue). Iloperidone (1-3 mg/kg) prevents the reduction in prepulse inhibition induced by apomorphine , phencyclidine (PCP), and cirazoline in rats. It also increases the time rats spend in the open arms of the elevated plus maze and the number of social interactions when administered at a dose of 0.5 mg/kg. Formulations containing iloperidone have been used in the treatment of schizophrenia.화학적 성질
Off-White Solid용도
Iloperidone (Fanapt, Fanapta, Zomaril) is an atypical antipsychotic for the treatment of schizophrenia. Iloperidone is a monoamine directed towards acting upon and antagonizing specific neurotransmitters, particularly multiple dopamine and serotonin recep정의
ChEBI: A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation a tipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia.일반 설명
Iloperidone is an atypical antipsychotic administered for the treatment of schizophrenia. The drug is marketed under the trade names Fanapt and Fanapta. This Certified Spiking Solution? is suitable for use in LC/MS or GC/MS applications including clinical toxicology, forensic testing, or pharmaceutical research.Clinical Use
Acting as an antagonist on serotonin (5-HT2) and dopamine receptor subtypes, iloperidone is an antipsychotic indicated for the treatment of acute schizophrenia in adults. Based on its in vitro and in vivo binding properties against both serotonin and dopamine receptors, it is expected that iloperidone will show fewer extrapyramidal symptoms than currently marketed antipsychotics such as haloperidol and clozapine. The original discovery was made by Hoechst-Roussel Pharmaceuticals who passed the developing rights to Vanda Pharmaceuticals and subsequently Novartis for marketing in the U.S. and Canada. While this drug was originally approved in the U.S. in 2009, the marketing was only initiated in the U.S. in 2010.아이로페리돈 준비 용품 및 원자재
원자재
준비 용품
아이로페리돈 공급 업체
글로벌( 354)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15371 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
아이로페리돈 관련 검색:
리스페리돈 1,2-벤지속사졸
3-Piperidin-4-ylbenzo[d]isoxazole
6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE(FOR RISPERIDONE&ILOPERIDONE)
Hydroxy Iloperidone
Desfluoro Iloperidone (IMpurity)
Iloperidone Carboxylic Acid
Iloperidone Diketo Impurity
Penfluridol
(Z)-(2,4-Difluorophenyl)-4-piperidinylmethanone oxime
Oxiracetam
Paliperidone
Ziprasidone
(E)-4-(2,4-Difluorobenzoyl)piperidine OxiMe
Ethanone, 1-(3-hydroxy-2-methoxyphenyl)- (9CI)
Iloperidone iMpurity
5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE
Iloperidone Impurity 21