N-(tert-Butoxycarbonyl)-L-phenylalanine

N-(tert-Butoxycarbonyl)-L-phenylalanine 구조식 이미지
카스 번호:
13734-34-4
상품명:
N-(tert-Butoxycarbonyl)-L-phenylalanine
동의어(영문):
BOC-PHE-OH;BOC-PHE;BOC-L-PHE-OH;BOC-L-PHE;BOC-L-PHENYLALANINE;N-BOC-L-PHENYLALANINE;BOC-PHENYLALANINE;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-;BOC-ph-OH;BOC Phenly Alanine
CBNumber:
CB4781305
분자식:
C14H19NO4
포뮬러 무게:
265.3
MOL 파일:
13734-34-4.mol
MSDS 파일:
SDS

N-(tert-Butoxycarbonyl)-L-phenylalanine 속성

녹는점
85-87 °C(lit.)
끓는 점
408.52°C (rough estimate)
밀도
1.1356 (rough estimate)
굴절률
24.5 ° (C=1, EtOH)
저장 조건
Keep in dark place,Sealed in dry,Room Temperature
용해도
메탄올, 디클로로메탄, 디메틸포름아미드 및 N-메틸-2-피롤리돈에 용해됩니다.
물리적 상태
미세 결정성 분말
산도 계수 (pKa)
3.88±0.10(Predicted)
색상
하얀색
optical activity
[α]20/D +25±1°, c = 1% in ethanol
BRN
2219729
CAS 데이터베이스
13734-34-4(CAS DataBase Reference)
EPA
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- (13734-34-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 36-22-36/37/38-20/21/22
안전지침서 39-26-36-24/25
WGK 독일 3
TSCA Yes
HS 번호 29242990
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
NFPA 704
1
0

N-(tert-Butoxycarbonyl)-L-phenylalanine MSDS


N-(tert-Butoxycarbonyl)-L-phenylalanine

N-(tert-Butoxycarbonyl)-L-phenylalanine C화학적 특성, 용도, 생산

화학적 성질

N-(tert-Butoxycarbonyl)-L-phenylalanine is white fine crystalline powder

용도

N-(tert-Butoxycarbonyl)-L-phenylalanine is used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.

제조 방법

Sodium hydroxide (4.4 g, 0.11 mol) was placed in a flask, and dissolved in water (110 mL). Phenylalanine (16.5 g, 0.1 mol) was added, the suspension was stirred until a solution was obtained, and then tert-butanol (75 mL) was added. Boc2O (22.3 g, 0.12 mol) was then added with stirring over a period of 1 h, keeping the mixture near 0 ℃. A white precipitate was produced, and at the end of the addition the pH had dropped to 7.5–8.5. The mixture was then carefully acidified by the slow, continuous addition of saturated citric acid to give the product N-tert-butoxycarbonyl-L-phenylalanine (21.5 g, 81%); mp 85℃; [a]21D = t25:5 (c = 1, ethanol).

N-(tert-Butoxycarbonyl)-L-phenylalanine 준비 용품 및 원자재

원자재

준비 용품


N-(tert-Butoxycarbonyl)-L-phenylalanine 공급 업체

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