신피브레이트

신피브레이트
신피브레이트 구조식 이미지
카스 번호:
14929-11-4
한글명:
신피브레이트
동의어(한글):
신피브레이트
상품명:
simfibrate
동의어(영문):
CLY-503;Sinfibrate;simfibrate;Cholesolvin;simfibrate USP/EP/BP;1,3-Propanediol bis[2-(4-chlorophenoxy)-2-methylpropionate];Propane-1,3-diyl bis(2-(4-chlorophenoxy)-2-methylpropanoate);Bis[2-(4-chlorophenoxy)-2-methylpropanoic acid] 1,3-propanediyl;Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 1,1'-(1,3-propanediyl) ester;3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methylpropanoate
CBNumber:
CB4875031
분자식:
C23H26Cl2O6
포뮬러 무게:
469.35
MOL 파일:
14929-11-4.mol

신피브레이트 속성

녹는점
51-53°
끓는 점
bp0.03 197-200°; bp0.15 220-230°
밀도
1.2623 (estimate)

안전

독성 LD50 in mice, rats (g/kg): 3.3-3.5; 7.3-8.0 orally (Nakanishi, J. Pharm. Soc. Japan)

신피브레이트 C화학적 특성, 용도, 생산

Originator

Cholesorbin,Takeda,Japan,1971

Manufacturing Process

A mixture of 22 grams of α-(p-chlorophenoxy)isobutyric acid, 3.8 grams of 1,3-propanediol, 0.5 gram of p-toluenesulfonic acid and 150 ml of xylene was refluxed. When the theoretically calculated amount of water had been removed, the xylene solution was washed with dilute aqueous sodium bicarbonate and then the xylene was distilled off. The residue was distilled under reduced pressure to give 11 grams (47% yield) of 1,3-propanediol bis[α-(p-chlorophenoxy)isobutyrate] boiling at 197° to 200°C/0.03 mm Hg.

Therapeutic Function

Antihyperlipidemic

신피브레이트 준비 용품 및 원자재

원자재

준비 용품


신피브레이트 공급 업체

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