피리트라마이드

피리트라마이드 C화학적 특성, 용도, 생산

화학적 성질

Off-White Low Melting Solid

Originator

Dipidolor ,Janssen W. ,Germany,1969

용도

Piritramide is a synthetic opioid commonly used in Germany and Austria for the analgesia of pediatric patients.

Manufacturing Process

A mixture of 84 parts of 3,3-diphenyl-3-cyanopropyl bromide, 41 parts of 4piperidino-4-piperidinecarboxamide, 64 parts of sodium carbonate, a small amount of potassium iodide and 1,200 parts of anhydrous toluene was stirred, and heated under reflux for 48 hours. At the end of this time the reaction mixture was allowed to cool to room temperature, and 500 parts of water were added. The resultant precipitate was removed by filtration, and triturated with diisopropyl ether. The crystalline material thus obtained was removed by filtration, and recrystallized from 320 parts of acetone, to give 1-(3,3diphenyl-3-cyanopropyl)-4-piperidino-4-piperidinecarboxamide, melting at about 149°C to 150°C.

Therapeutic Function

Analgesic

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원자재

준비 용품

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