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엽산 구조식 이미지
카스 번호:
Folic acid
포뮬러 무게:
MOL 파일:

엽산 속성

250 °C
20 º (c=1, 0.1N NaOH)
끓는 점
552.35°C (rough estimate)
1.4704 (rough estimate)
1.6800 (estimate)
저장 조건
boiling water: soluble1%
산도 계수 (pKa)
pKa 2.5 (Uncertain)
물리적 상태
Crystalline Powder
Yellow to orange
pH 범위
1.6 mg/L (25 ºC)
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
CAS 데이터베이스
59-30-3(CAS DataBase Reference)
Folic acid(59-30-3)
L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (59-30-3)
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 33-62-68
안전지침서 24/25
WGK 독일 1
RTECS 번호 LP5425000
F 고인화성물질 8
HS 번호 29362900
유해 물질 데이터 59-30-3(Hazardous Substances Data)
기존화학 물질 KE-01305
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.


N-4-[(2-Amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-L-glutamic acid

엽산 C화학적 특성, 용도, 생산


엽산은 말린 콩, 완두, 렌즈 콩, 오렌지, 간, 아스파라거스, 사탕무, 브로콜리, 브뤼셀 콩나물, 시금치와 같은 식품에서 쉽게 발견 할 수있는 B 비타민 (비타민 B9)의 한 종류입니다. 새로운 건강한 세포를 만드는 능력으로, 엽산은 임산부에게 중요합니다. 임신 전이나 임신 중 엽산 결핍은 아기의 척추 또는 뇌의 주요 출생 결함을 예방할 수 있습니다.


물에서 불용해성 공기 & 물 반응. 수성 해결책에는 4.0-4.8의 pHs가 있습니다.
엽산의 반응성 단면도 산성 해결책은 열에 과민합니다, 그러나 중립성으로, 안정성은 진보적으로 증가합니다. 해결책은 자외선에 의해 활동되지 않고 알칼리성 해결책은 산화에 과민합니다. 엽산은 또한 빛에 의해 활동되지 않ㅂ니다. 엽산은 산화제, 감소시키는 대리인 및 중금속 이온에 상반됩니다. 엽산의 화재의 원인이 되는 것 인화점 데이터는 유효하지 않습니다; 그러나, 엽산은 아마 가연성 입니다


엽산 (비타민 B9)은 엽산이라고 불리는 비타민 B를 인간이 만들었습니다. 우리 몸이 적혈구를 생성하는 것은 매우 중요합니다. 엽산은 강화 시리얼에 존재합니다. 임산부 또는 임신 준비가되어있는 사람들에게 널리 사용됩니다. 엽산 (비타민 B9)은 유산이나 아기의 자연적인 굴절 또는 조기 진통의 위험을 크게 줄입니다. 엽산 보충제는 모든 의사의 조언에 의한 것입니다.
모든 사람의 건강을 위해 엽산 결핍으로 빈혈이 유발됩니다. 엽산은 다른 약물과 함께 사용하거나 혼자서이 문제를 치료할 수 있습니다. 예 : 푸마르산 철 및 엽산 정
신장 질환, 빈혈로 고통 받고 있거나 대개 많이 마시면 ​​의사의 전문 지식을 따라 엽산을 섭취하십시오.

제품 소개

엽산은 말린 콩, 완두, 렌즈 콩, 오렌지, 간, 아스파라거스, 사탕무, 브로콜리, 브뤼셀 콩나물, 시금치와 같은 식품에서 쉽게 발견 할 수있는 B 비타민 (비타민 B9)의 한 종류입니다. 새로운 건강한 세포를 만드는 능력으로, 엽산은 임산부에게 중요합니다. 임신 전이나 임신 중 엽산 결핍은 아기의 척추 또는 뇌의 주요 출생 결함을 예방할 수 있습니다.
엽산 (비타민 B9) 원료 인 API는 새로운 세포를 생산하고 유지하는 데 도움이되며 암으로 이어질 수있는 DNA의 변화를 막아줍니다. 제약 분야에서 엽산은 주로 엽산 결핍으로 인한 엽산 (비타민 B9) 결핍 및 특정 유형의 빈혈 (적혈구 부족)을 치료하는 데 사용됩니다. 때로는 엽산 (비타민 B9)이 다른 약물과 함께 악성 빈혈을 치료합니다. 우리가 더 잘 알아야 할 것은, 엽산 (비타민 B9)이 비타민 B12 결핍증에 효과적이지 않으며 척수 손상을 예방하지 않는다는 것입니다.


In the 1930s, brewer’s yeast was found to prevent anemia. Folic acid was later discovered to be the nutrient responsible for this effect and was purified in 1941 by Mitchell and coworkers (Mitchell et al., 1941). Folate is needed for biosynthesis of purines and thymidine for DNA and RNA synthesis in all cells. It is also involved in metabolism of some of the amino acids needed for protein synthesis, especially the conversions of serine to glycine and homocysteine to methionine. This makes the nutrient especially important during periods of rapid cell division, such as in pregnancy. Folate is also involved in transfer of one-carbon groups for methylation reactions. The role of folate in cell division was capitalized upon in the synthesis of aminopterin, a folate antagonist, which was one of the first anticancer drugs produced.

화학적 성질

orange to yellow crystalline powder

물리적 성질

The folates include a large number of chemically related species, each differing with respect to the various substituents possible at three sites on the pteroylglutamic acid basic structure. More than 170 different folates are theoretically possible. Not all of these occur in nature; but it has been estimated that as many as 100 different forms are found in animals. The folates from most natural sources usually have a single carbon unit at N-5 and/or N-10; these forms participate in the metabolism of the single-carbon pool.
Folic acid (pteroylmonoglutamic acid) is an orange-yellow crystalline substance that is soluble in water but insoluble in ethanol or less polar organic solvents. It is unstable to light, to acidic or alkaline conditions, to reducing agents, and, except in dry form, to heat. It is reduced in vivo enzymatically (or in vitro with a reductant such as dithionite) first to 7,8-dihydrofolic acid (FH2) and then to FH4; both of these compounds are unstable in aerobic environments and must be protected by the pres ence of an antioxidant (e.g., ascorbic acid, 2-mer
Two derivatives of folic acid, each having an amino group in the place of the hydroxyl at C-4, are folate antagonists of biomedical use: aminopterin (4-aminofolic acid) and methotrexate (4-amino-N10-methylfolic acid). Aminopterin is used as a rodenticide; methotrexate is an antineoplastic agent.


Folvite, Lederle, US ,1946




Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.


Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.


folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.


A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.


hematopoietic vitamin


ChEBI: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.

Manufacturing Process

The following description is taken from US Patent 2,956,057.
100 grams of 1,3,3-trichloroacetone are heated on a boiling water bath and 95 grams of bromine are added thereto in drops while being stirred and the stirring is continued for about 1 hour. The resulting reaction solution is distilled under reduced pressure. 115 grams of 1-bromo-1,3,3- trichloroacetone are obtained having a boiling point of 85° to 95°C/17 mm (Hg).
For the preparation of the hydrate, 100 grams of water are added to 100 grams of 1bromo-1,3,3-trichloroacetone, which is agitated and cooled. A white scaly crystal of hydrate of 1-bromo-1,3,3-trichloroacetone is obtained (100 grams), having a melting point of 52° to 53°C.
8.9 grams of 2,4,5-triamino-6-hydroxypyrimidine hydrochloride and 8 grams of p-aminobenzoylglutamic acid are dissolved in 400 cc warm water, which is cooled at 35° to 27°C and adjusted to pH 4 by using 20% caustic soda solution. To this solution was simultaneously added dropwise a solution obtained by dissolving 13.4 grams of 1-bromo-1,3,3-trichloroacetone hydrate in 90 cc of 50% methanol and 24 grams of 35% aqueous sodium bisulfite solution over a period of approximately 2 hours. During this period, in order to maintain the pH value of the reaction solution at 4 to 5, 20% caustic soda solution is added from time to time. The precipitate, formed by stirring for 5 hours after dropping was finished, is filtered, and the filtrated precipitate is refined; 5.6 grams of pure pteroylglutamic acid is obtained.

Therapeutic Function

Treatment of B vitamin (folacin) deficiency

일반 설명

Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.

공기와 물의 반응

Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.

반응 프로필

Acid solutions of Folic acid are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Folic acid is also inactivated by light. Folic acid is incompatible with oxidizing agents, reducing agents and heavy metal ions.


Flash point data for Folic acid are not available; however, Folic acid is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Folic acid is used to treat folic acid deficiency in dogs, cats, and horses (theoretically in other animal species as well) often due to small intestinal disease. Cats with exocrine pancreatic insufficiency appear to be most at risk for folate and cobalamin deficiencies secondary to malabsorption of folic acid in the diet. Dogs with exocrine pancreatic insufficiency often are noted to have increased folate levels secondary to overgrowths of folate-synthesizing bacteria in the proximal small intestine. Chronic administration of dihydrofolate reductase inhibiting drugs such as pyrimethamine, ormetoprim or trimethoprim can potentially lead to reduced activated folic acid (tetrahydrofolic acid); folic acid supplementation is sometimes prescribed in an attempt to alleviate this situation.

Purification Methods

If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.]

엽산 준비 용품 및 원자재


준비 용품

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