Pentamidine isethionate
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Pentamidine isethionate 속성
- 녹는점
- 188-194 °C(lit.)
- 저장 조건
- 2-8°C
- 용해도
- 물에 잘 녹고, 에탄올(96%)에 조금 녹고, 염화메틸렌에는 거의 녹지 않습니다.
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- Merck
- 13,7192
- 안정성
- 흡습성
- InChIKey
- YBVNFKZSMZGRAD-UHFFFAOYSA-N
- CAS 데이터베이스
- 140-64-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-43 | ||
| 안전지침서 | 26-36/37 | ||
| 유엔번호(UN No.) | 3249 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | CV6500000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 2925294500 | ||
| 독성 | LD50 intraperitoneal in mouse: 63mg/kg |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Pentamidine isethionate C화학적 특성, 용도, 생산
화학적 성질
White or almost white powder or colourless crystals, hygroscopic.용도
Pentamidine isethionate salt has been used:- as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays
- as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K+ channel trafficking
- as an anti-leishmanial agent in promastigotes
정의
ChEBI: An organosulfonate salt obtained by reaction of pentamidine with two equivalents of 2-hydroxyethylsulfonic acid.일반 설명
Odorless white or almost white crystals or powder. Odor also reported as a slight butyric odor. Very bitter taste. pH (5% aqueous solution) 4.5-6.5.공기와 물의 반응
Hygroscopic. May be sensitive to prolonged exposure to air. Aqueous solutions deteriorate on storage. Water soluble.반응 프로필
Can decompose on prolonged exposure to light.화재위험
Flash point data for Pentamidine isethionate are not available; however, Pentamidine isethionate is probably combustible.생물학적 활성
Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.Clinical Use
4,4’-(Pentamethylenedioxy)dibenzamidine diisethionate(NebuPent, Pentam 300) is a water-soluble crystalline saltthat is stable to light and air. The principal use of pentamidineis for the treatment of pneumonia caused by the opportunisticpathogenic protozoan P. carinii, a frequent secondaryinvader associated with AIDS. The drug may beadministered by slow intravenous infusion or by deep intramuscularinjection for PCP. An aerosol form of pentamidineis used by inhalation for the prevention of PCP inhigh-risk patients infected with HIV who have a previoushistory of PCP infection or a low peripheral CD4+ lymphocytecount.Pentamidine has been used for the prophylaxis and treatmentof African trypanosomiasis. It also has some value fortreating visceral leishmaniasis. Pentamidine rapidly disappearsfrom the plasma after intravenous injection and is distributedto the tissues, where it is stored for a long period.This property probably contributes to the usefulness of thedrug as a prophylactic agent.
Pentamidine isethionate 준비 용품 및 원자재
원자재
준비 용품
Pentamidine isethionate 공급 업체
글로벌( 188)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12452 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8822 | 58 |
| Wuhan Chemwonders Technology Inc. | 027-85778276 |
info@chemwonders.com | CHINA | 176 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
Pentamidine isethionate 관련 검색:
소듐 아이세티오네이트
2,5-dihydroxybenzenesulphonic acid
Hyaluronidase
4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
Pentamidine
Sulfonates
Lignin Sulfonate
BENZAMIDINE
4-METHOXYBENZAMIDINE FOR FLUORESCENCE
4-BUTOXYBENZYLAMINE
4-ETHOXY-BENZAMIDINE
4-HYDROXY-BENZAMIDINE
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate
4-PROPYLOXYBENZYLAMINE
4-ETHOXY-BENZYLAMINE
4-PENTYLOXYBENZYLAMINE
Pentamidine isethionate