Telatinib
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Telatinib 속성
- 끓는 점
- 713.6±60.0 °C(Predicted)
- 밀도
- 1.417
- 저장 조건
- Store at -20°C
- 용해도
- insoluble in H2O; insoluble in EtOH; ≥20.5 mg/mL in DMSO
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 14.18±0.46(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Telatinib C화학적 특성, 용도, 생산
개요
Telatinib is a multi-kinase inhibitor that inhibits VEGF receptor 2 (VEGFR2), VEGFR3, PDGFRα, and c-Kit (IC50s = 6, 4, 15, and 1 nM, respectively). It also binds to the transmembrane region of the ABCG2 efflux transporter and enhances intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells. Telatinib (15 mg/kg) decreases tumor growth rate and size in an H460/MX20 mouse xenograft model.용도
Telatinib (BAY 57-9352) is an orally available, potent multitargeted VEGFR-2, VEGFR-3, PDGFR-β and c-Kit tyrosine kinases inhibitor with an IC50 of 19 nM for the inhibition of VEGFR-2 autophosphorylation.Telatinib 준비 용품 및 원자재
원자재
Furo[2,3-d]pyridazin-7-amine, 4-chloro-N-(4-chlorophenyl)-
Furo[2,3-d]pyridazine, 4,7-dichloro
4-(hydroxymethyl)-N-methylpicolinamide
FURAN-2,3-DICARBOXYLIC ACID
(2-METHYLAMINOCARBONYL-4-PYRIDYL)METHANOL
2-METHYLCARBAMOYLISONICOTINIC ACID ETHYL ESTER
Furo[2,3-d]pyridazin-4-amine, 7-chloro-N-(4-chlorophenyl)-
5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione
2,3-furandicarboxylic acid dimethyl ester
푸란-3-카르복실산
노르말메틸포름아미드
Ethyl isonicotinate
준비 용품
Telatinib 공급 업체
글로벌( 122)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |