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에틸파라벤

에틸파라벤
에틸파라벤 구조식 이미지
카스 번호:
120-47-8
한글명:
에틸파라벤
동의어(한글):
에틸파라벤;파라옥시안식향산에틸;P-옥시안식향산에틸;에틸파라벤;P-카르브에톡시페놀;4-(에톡시카르보닐)페놀;에틸4-;에틸파라벤
상품명:
Ethylparaben
동의어(영문):
Ethyl;Sobrol A;nipazina;solbrola;Of ethyl;Solbro A;Easeptol;Keloform;Mycocten;napagina
CBNumber:
CB5119772
분자식:
C9H10O3
포뮬러 무게:
166.17
MOL 파일:
120-47-8.mol

에틸파라벤 속성

녹는점
114-117 °C(lit.)
끓는 점
297-298 °C(lit.)
밀도
1.1708 (rough estimate)
증기압
0.00012 hPa (25 °C)
굴절률
1.5286 (estimate)
인화점
297-298°C
저장 조건
0-6°C
용해도
Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
물리적 상태
Crystalline Powder
색상
White
수소이온지수(pH)
4.5-5.5 (H2O, 20°C) (saturated solution)
수용성
Slightly soluble in water.
Merck
14,3837
BRN
1101972
안정성
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS 데이터베이스
120-47-8(CAS DataBase Reference)
NIST
Ethylparaben(120-47-8)
EPA
Benzoic acid, 4-hydroxy-, ethyl ester(120-47-8)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36-24/25
WGK 독일 1
RTECS 번호 DH2190000
자연 발화 온도 495 °C
TSCA Yes
HS 번호 29182930
유해 물질 데이터 120-47-8(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 2000 mg/kg
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P272 작업장 밖으로 오염된 의복을 반출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

에틸파라벤 MSDS


p-Hydroxybenzoate ethyl ester

에틸파라벤 C화학적 특성, 용도, 생산

화학적 성질

white crystalline powder

화학적 성질

Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder.

용도

An antimicrobial

용도

bronchodilator, tocolytic

용도

Preservative for pharmaceuticals.

생산 방법

Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%).

Pharmaceutical Applications

Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations.
It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline.

색상 색인 번호

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.52 g/kg
LD50 (mouse, oral): 3.0 g/kg

저장

Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).
Ethylparaben should be stored in a well-closed container in a cool, dry place.

비 호환성

The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy.
Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

에틸파라벤 준비 용품 및 원자재

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