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NFPA 704
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2
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol C화학적 특성, 용도, 생산
개요
Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.
용도
Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol 준비 용품 및 원자재
원자재
준비 용품
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol 공급 업체
