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paraherquamide

paraherquamide 구조식 이미지
카스 번호:
77392-58-6
상품명:
paraherquamide
동의어(영문):
VM 29919;paraherquamide;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10'(10H)-dione, 2',3',8'a,9'-tetrahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
CBNumber:
CB51336725
분자식:
C28H35N3O5
포뮬러 무게:
493.59
MOL 파일:
77392-58-6.mol

paraherquamide 속성

녹는점
244-247° (dec)
알파
D22 -28° (c = 0.43 in methanol)
물리적 상태
White to off-white powder.

안전

paraherquamide C화학적 특성, 용도, 생산

개요

Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg).

용도

Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

용도

Paraherquamide A is a selective, competitive, cholinergic antagonist.

paraherquamide 준비 용품 및 원자재

원자재

준비 용품


paraherquamide 공급 업체

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