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(-)-Arctigenin

(-)-Arctigenin 구조식 이미지
카스 번호:
7770-78-7
상품명:
(-)-Arctigenin
동의어(영문):
ARCTIGENIN;ARCTIGENIN(P);(-)-ARCTIGENIN;The arctigenin;(-)-Arctigenin, 98%, from Arctium lappa L.;2(3H)-Furanone,4-[(3,4-dimethoxyphenyl) methyl];dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R,4R)-;(3R,4R)-3-(3-Methoxy-4-hydroxybenzyl)-4-(3,4-dimethoxybenzyl)tetrahydrofuran-2-one;(3R)-3α-(3-Methoxy-4-hydroxybenzyl)-4β-(3,4-dimethoxybenzyl)-4,5-dihydrofuran-2(3H)-one;(3R,4R)-3-(4-Hydroxy-3-methoxybenzyl)-4-(3,4-dimethoxybenzyl)-4,5-dihydrofuran-2(3H)-one
CBNumber:
CB5136742
분자식:
C21H24O6
포뮬러 무게:
372.41
MOL 파일:
7770-78-7.mol

(-)-Arctigenin 속성

녹는점
98.0 to 102.0 °C
저장 조건
−20°C
용해도
DMSO: 34 mg/mL with heating and sonicating, soluble
물리적 상태
solid
최대 파장(λmax)
280nm(EtOH)(lit.)
InChIKey
NQWVSMVXKMHKTF-JKSUJKDBSA-N
CAS 데이터베이스
7770-78-7(CAS DataBase Reference)

안전

안전지침서 22-24/25
WGK 독일 3
RTECS 번호 LY9247000

(-)-Arctigenin C화학적 특성, 용도, 생산

생물학적 활성

Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of I κ B α phosphorylation and p65 nuclear translocation (IC 50 = 10 nM). Inhibits HIV-1 replication in vitro . Also potently inhibits MKK1 (IC 50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

효소 저해제

This plant lignan (FW = 372.41 g/mol; CAS 7770-78-7; IUPAC: (3R,4R)- 4-[(3,4-dimethoxy-phenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl) methyl]-2-tetrahydrofuranone) is a functional ingredient of several traditional Chinese herbs and dose-dependently reduces proliferation of human dermal microvascular endothelial cells without altering their migratory and tube-forming capacity. Arctigenin treatment also resulted in a decreased cellular expression of phosphorylated serine/threonine protein kinase AKT, vascular EGFR2, and proliferating cell nuclear antigen and inhibited vascular sprouting from aortic rings.

(-)-Arctigenin 준비 용품 및 원자재

원자재

준비 용품


(-)-Arctigenin 공급 업체

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