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Cefpodoxime proxetil

Cefpodoxime proxetil 구조식 이미지
카스 번호:
87239-81-4
상품명:
Cefpodoxime proxetil
동의어(영문):
BANAN;ORELOX;OTREON;R-3763;VANTIN;CS-807;JP,USP;U-76252;U-76253;CEFODOX
CBNumber:
CB5150483
분자식:
C21H27N5O9S2
포뮬러 무게:
557.6
MOL 파일:
87239-81-4.mol

Cefpodoxime proxetil 속성

녹는점
111-113°C
밀도
1.58±0.1 g/cm3(Predicted)
RTECS 번호
XI0367370
저장 조건
-20?C Freezer
용해도
Soluble in DMSO
물리적 상태
neat
산도 계수 (pKa)
8.13±0.60(Predicted)
감도
Light Sensitive
InChIKey
LTINZAODLRIQIX-FBXRGJNPSA-N
CAS 데이터베이스
87239-81-4(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38-42/43
안전지침서 22-26-36/37/39
WGK 독일 3
HS 번호 30042000
독성 LD50 in male, female mice, male, female rats (mg/kg): >10000, >10000, >2000, >2000 s.c., 3502, 2535, >4000, >4000 i.p.; >8000, >8000, >4000, >4000 orally (Nakao, 1988)
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음 호흡기 과민성 물질 구분 1 위험 P261, P285, P304+P341, P342+P311,P501
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P284 호흡 보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.

Cefpodoxime proxetil C화학적 특성, 용도, 생산

개요

Cefpodoxime proxetil is an orally active, broad-spectrum cephalosporin especially useful in the treatment of bacterial infections in children. It is a prodrug converted by esterases in the GI walls to cefpodoxime, which reportedly has a bacteriostatic spectrum comparable to injectable third-generation cephem antibiotics.

화학적 성질

Pale Yellow Solid

Originator

Sankyo (Japan)

용도

A metabolite of Cefpodoxime Proxetil. An antibacterial.

용도

An antibacterial. A broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime

정의

ChEBI: The 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pha yngitis, and sinusitis.

상표명

Vantin (Pharmacia & Upjohn);Banan.

Clinical Use

Cefpodoxime proxetil (Vantin) is the isopropyloxycarbonylethylester of the third-generation cephalosporincefpodoxime. This orally active prodrug derivative is hydrolyzedby esterases in the intestinal wall and in theplasma to provide cefpodoxime. Tablets and a powder forthe preparation of an aqueous suspension for oral pediatricadministration are available. The oral bioavailability of cefpodoximefrom the proxetil is estimated to be about 50%.Administration of the prodrug with food enhances its absorption.The plasma half-life is 2.2 hours, which permitsadministration on a twice-daily schedule.
Cefpodoxime is a broad-spectrum cephalosporin withuseful activity against a relatively wide range of Grampositiveand Gram-negative bacteria. It is also resistant tomany β-lactamases. Its spectrum of activity includes S.pneumoniae, Streptococcus pyogenes, S. aureus, H. influenzae,M. catarrhalis, and Neisseria spp. Cefpodoxime is alsoactive against members of the Enterobacteriaceae family,including E. coli, K. pneumoniae, and P. mirabilis. It thusfinds use in the treatment of upper and lower respiratory infections,such as pharyngitis, bronchitis, otitis media, andcommunity-acquired pneumonia. It is also useful for thetreatment of uncomplicated gonorrhea.

Veterinary Drugs and Treatments

In dogs, cefpodoxime is indicated for the treatment of skin infections caused by Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis, E. coli, Proteus mirabilis, and Pasteurella multocida. Although not currently approved for cats, it may also be useful as well.

Cefpodoxime proxetil 준비 용품 및 원자재

원자재

준비 용품


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