사이클렌
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사이클렌 속성
- 녹는점
- 110-113 °C (lit.)
- 끓는 점
- 292.61°C (rough estimate)
- 밀도
- 1.0415 (rough estimate)
- 증기압
- 0.004Pa at 20℃
- 굴절률
- 1.5872 (estimate)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 10.53±0.20(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 거의 흰색에서 약간 노란색
- 수용성
- 거의 투명함
- BRN
- 606114
- 안정성
- 흡습성
- InChIKey
- QBPPRVHXOZRESW-UHFFFAOYSA-N
- LogP
- -0.63 at 20℃
- CAS 데이터베이스
- 294-90-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/38-36/37/38 | ||
| 안전지침서 | 26-36 | ||
| 유엔번호(UN No.) | 1759 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | XA5253000 | ||
| F 고인화성물질 | 3-9-34 | ||
| 위험 참고 사항 | Irritant | ||
| 위험 등급 | 8 | ||
| 포장분류 | II | ||
| HS 번호 | 29339900 |
사이클렌 C화학적 특성, 용도, 생산
화학적 성질
almost white to slightly yellow crystalline powder, soluble in methanol, ethanol, dmso and other organic solvents, derived from stephania cepharantha.용도
Cyclen is an azamocrocycle, which can be used in the development of fluorescent nanosensors for the detection of metal ions.주요 응용
Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well ass other imaging) agents.일반 설명
Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.Synthesis
Some syntheses exploit the Thorpe-Ingold effect to facilitate ring-formation. Illustrative is the reaction of the deprotonated tosylamides with ditosylates:TsN(CH2CH2NTsNa)2 + TsN(CH2CH2OTs)2 → (TsNCH2CH2)4
The resulting macrocycle can be deprotected with strong acid. Base gives the tetramine.
High dilution conditions result in a low reaction rate penalty and this disadvantage is removed in an alternative procedure starting from triethylenetetraamine and dithiooxamide to a bisamidine – also a bis(imidazoline) – followed by reduction and ring expansion with DIBAL.
In one study cyclen is covalently bonded through a propylene molecular spacer to adenine and chelated with zinc diperchlorate. This complex is able to selectively bind uracil and uridine in a 1:2 ratio both through the adenine part and cyclen part of the molecule as evidenced by mass spectrometry.
wiki/Cyclen
사이클렌 준비 용품 및 원자재
원자재
다이에틸렌트라이아민
다이에탄올아민
파라-톨루엔설폰일 염화물
메틸산 나트륨
초산에틸
염산
아세트산(빙초산)
이소프로필에테르
피리딘
황산
1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE
1-Bromo-2-iodoethane
사이클렌 테트라하이드로클로라이드
1-브로모-2-클로로에탄
1,2-DIIODOETHANE
에틸렌 디브롬
준비 용품
사이클렌 공급 업체
글로벌( 565)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2966 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| PRISUN PHARMATECH CO.,LTD | +86-021-54326183-8001 +8618917565227 |
prisun@prisunpharma.com | China | 215 | 58 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
| Changzhou Zechong Biopharma Co., Ltd. | +undefined18621330623 |
sales@zechongchem.com | China | 28 | 58 |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 |
trade.kilopharma@foxmail.com | China | 27 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 |
sales@anbuchem.com | China | 3000 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7377 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |