시클로스포린 A
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시클로스포린 A 속성
- 녹는점
- 148-151°C
- 끓는 점
- 838.63°C (rough estimate)
- 알파
- D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol)
- 밀도
- 0.9913 (rough estimate)
- 굴절률
- 1.6500 (estimate)
- 인화점
- 87℃
- 저장 조건
- -20°C
- 용해도
- 에탄올: 30mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 13.32±0.70(Predicted)
- 색상
- 하얀색
- 수용성
- 디메틸설폭사이드와 에탄올에 용해됩니다. 물에 불용성.
- Merck
- 14,2752
- BRN
- 3647785
- 안정성
- 공급된 상태로 3년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- PMATZTZNYRCHOR-CGLBZJNRSA-N
- CAS 데이터베이스
- 59865-13-3(CAS DataBase Reference)
- IARC
- 1 (Vol. 50, 100A) 2012
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn,F | ||
---|---|---|---|
위험 카페고리 넘버 | 45-60-22-40-36-20/21/22-11 | ||
안전지침서 | 53-45-36/37-24/25-22-26-16 | ||
유엔번호(UN No.) | UN 1648 3 / PGII | ||
WGK 독일 | 3 | ||
RTECS 번호 | GZ4120000 | ||
HS 번호 | 29419090 | ||
유해 물질 데이터 | 59865-13-3(Hazardous Substances Data) | ||
독성 | LD50 in mice, rats, rabbits (mg/kg): 107, 25, >10 i.v.; 2329, 1480, >1000 orally (Ryffel) |
시클로스포린 A C화학적 특성, 용도, 생산
개요
Cyclosporine A is a powerful immunosuppressive drug intended for preventing rejection of kidney, heart, and lung transplants. A new era in the development of immunopharmacology began with the discovery of cyclosporines. Cyclosporines are produced by mycelial mushrooms Tolypocladium inflatum, Tricoderma polysporum, and Cylindrocarpon lucidum, which are found in the ground.Cyclosporine A is the first drug to affect a specific line of protecting cells of the body. Unlike usual cytotoxics, it suppresses T-cells and acts on all cell lines simultaneously. Cyclosporine A significantly eases the ‘reception’ of transplants, and increases the possibility of treating autoimmune system diseases.
화학적 성질
White or almost white powder용도
Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα.정의
ChEBI: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibiti n of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.Indications
일반 설명
White prismatic needles (from acetone) or white powder.공기와 물의 반응
Slightly water soluble .반응 프로필
Cyclosporin A is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).건강위험
SYMPTOMS: Symptoms of exposure to Cyclosporin A include hepatotoxicity, nephrotoxicity, hyperkalemia, hyperuricemia, convulsions, renal dysfunction, tremor, hirsutism, hypertension, gum hyperplasia, cramps, acne, headache, diarrhea, nausea, vomiting, abdominal discomfort, paresthesia, flushing, leukopenia, lymphoma, sinusitis and gynecomastia. In 2% or less of persons exposed, it has caused allergic reactions, anemia, anorexia, confusion, conjunctivitis, edema, fever, brittle fingernails, gastritis, hearing loss, hiccups, hyperglycemia, muscle pain, peptic ulcer, thrombocytopenia and tinnitus. Rare reactions include anxiety, chest pain, constipation, depression, hair breaking hematuria, joint pain, lethargy, mouth sores, myocardial infarction, night sweats, pancreatitis, pruritus, swallowing difficulty, tingling, upper gastrointestinal bleeding, visual disturbance, weakness and weight loss. It has caused kidney and liver damage. An increased susceptibility to infection may occur. Other symptoms include gastrointestinal disturbance, rashes and angioedema.화재위험
Flash point data for Cyclosporin A are not available; however, Cyclosporin A is probably combustible.Pharmacology
Cyclosporine has no direct effect on keratinocytes and is not a mitotic inhibitor. Cyclosporine inhibits cytokine release, which results in a decreased recruitment of APCs into the epidermis and decreases immunoreactivity of lesions. Potential long-term side effects preclude cyclosporine’s use in all but very severe and recalcitrant psoriasis. Cyclosporine can be combined with lowdose methotrexate.부작용
Cyclosporine’s main side effects, even at low doses, are hypertension and nephrotoxicity. Age, baseline blood pressure, and baseline creatinine levels are predictors of higher risks of side effects. Glomerular filtration rate (GFR) is a more sensitive test than creatinine for evaluating renal function, and a baseline is recommended in any high-risk patient. Longterm treatment with CSA may induce interstitial fibrosis and glomerular sclerosis, with more pronounced changes directly associated with duration of therapy. It should be administered only by dermatologists experienced in its use.Safety Profile
Confirmed carcinogen producing Hodghn's dlsease. Experimental reproductive effects. Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: increased body temperature, cyanosis. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.잠재적 노출
Cyclosporin A is a fungal metabolite; an amide immunosuppressant drug used in various surgeries.Carcinogenicity
Cyclosporin A is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.운송 방법
UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.비 호환성
Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents such as hydrideds and active metals. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as such as phosphorus pent- oxide or thionyl chloride generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).폐기물 처리
t is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consider- ation applicable DEA, EPA, and FDA regulations. If possi- ble return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.시클로스포린 A 준비 용품 및 원자재
원자재
준비 용품
시클로스포린 A 공급 업체
글로벌( 650)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8619133911216 |
fanfan@kangcang.com.cn | China | 340 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 893 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
시클로스포린 A 관련 검색:
염산미노사이클린 시클로스포린 시클로스포린 A
Val2-cyclosporine,CYCLOSPORIN D
Clindamycin
Oxytetracycline dihydrate
CYCLOSPORIN C,Thr2-cyclosporine
STAUROSPORINE
Gentamicin
Azithromycin
CYCLOSPORIN H
Antibiotic
cyclosporin G
CYCLOSPORINE RESOLUTION MIXTURE (25 MG)
CYCLOSPORIN B,Ala2-cyclosporine
PIERICIDIN A
Cyclosporine A acetate
(melle-4)cyclosporin