클로미프라민
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클로미프라민 속성
- 녹는점
- 189.5°C
- 끓는 점
- bp0.3 160-170°
- 밀도
- 1.0568 (rough estimate)
- 굴절률
- 1.5749 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- H2O: 25 mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- pKa 9.38(H2O) (Uncertain)
- 색상
- 흰색에서 황백색까지
- CAS 데이터베이스
- 303-49-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 20/21/22 | ||
안전지침서 | 36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | HN9055000 | ||
유해 물질 데이터 | 303-49-1(Hazardous Substances Data) |
그림문자(GHS): | ||||||||||||||||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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클로미프라민 C화학적 특성, 용도, 생산
용도
Antidepressan.정의
ChEBI: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressan s, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.Mechanism of action
Clomipramine is different from the other TCAs, exhibiting preferential selectivity for inhibiting the reuptake of 5-HT at the presynaptic neuronal membrane. Its antidepressant mechanism of action as an inhibitor of the 5-HT transporter is reduced in vivo, however, because of the formation of its active metabolite, N-desmethylclomipramine, which inhibits the reuptake of NE. As a result of its common structure with the other TCAs, clomipramine shares the pharmacological and adverse-effect profile of the other TCAs.The efficacy of clomipramine relative to the other TCAs in the treatment of obsessive-compulsive disorder may be related to its potency in blocking 5-HT reuptake at the presynaptic neuronal membrane, suggesting a dysregulation of 5-HT for the pathogenesis of obsessive-compulsive disorder. Clomipramine appears to decrease the turnover of 5-HT in the CNS, probably because of a decrease in the release and/or synthesis of 5-HT.
Although in vitro studies suggest that clomipramine is approximately four times more potent than fluoxetine as a 5-HT reuptake inhibitor, in vivo studies suggest the opposite. This difference has been attributed to the relatively long elimination half-lives for fluoxetine and its principal serotonergic metabolite norfluoxetine. In addition, metabolism of clomipramine to its N-desmethyl secondary amine metabolite decreases the potency and selectivity of 5-HT -reuptake inhibition of clomipramine, but not fluoxetine.
Clinical Use
Clomipramine is considered to be the most powerful antidepressant ever made. This dihydrodibenzazepine TCA, with actions on both the NE and 5-HT transporters, was the last of the major TCAs to come to market. Initially, the U.S. FDA regarded it as another “me-too” drug, and accordingly, they did not license it. Subsequently, however, it was licensed for the treatment of obsessive-compulsive disorders. Clomipramine differs from imipramine only by the addition of a 3-chloro group.부작용
Male patients taking clomipramine should be informed of sexual dysfunction as a side effect associated with antidepressants having significant serotonergic activity. Sexual dysfunction in men appears as ejaculatory incompetence, ejaculatory retardation, decreased libido, or inability to obtain or maintain an erection. Sexual dysfunction is dose-related and may be treated by simply lowering the drug dose.클로미프라민 준비 용품 및 원자재
원자재
준비 용품
클로미프라민 공급 업체
글로벌( 122)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
클로미프라민 관련 검색:
디메틸 에테르 다이메틸 푸마르산 에탄 다이메틸 프탈레이트 디하이드로미르세놀 N,N-다이메틸폼아마이드 다이메틸 설폭사이드 황화디메틸 터트-뷰틸클로로다이메틸실란 클로르디아제프
DIMETHYLTHEXYLSILYL CHLORIDE
IMIPRAMINE
Clomifene
Chlorodimethylphenylsilane
Imipramine hydrochloride
1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE
CLOMIPRAMINE HYDROCHLORIDE,CLOMIPRAMINE HCL,CLOMIPRAMINE HYDROCHLORIDE \ SEROTONIN U PTAKE INHIBITOR, ANTIDEPRESSANT
D/L-AMPHETAMINE HYDROCHLORIDE