DL-6,8-티옥트 산

DL-6,8-티옥트 산
DL-6,8-티옥트 산 구조식 이미지
카스 번호:
1077-28-7
한글명:
DL-6,8-티옥트 산
동의어(한글):
리포산;DL-6,8-티옥트산;DL-6,8-티옥트산(DL-6,8-THIOCTICACID);티옥틱애씨드
상품명:
α-Lipoic Acid
동의어(영문):
ALA;THIOCTIC ACID;ALPHA-LIPOIC ACID;ALPHA-LIPOIC ACID;DL-THIOCTIC ACID;Thioctic acid CRS;A-LIPOIC ACID;alpha lipoic acid powder;DL-A-LIPOIC ACID;Alpha Acid Lipoic
CBNumber:
CB5180699
분자식:
C8H14O2S2
포뮬러 무게:
206.33
MOL 파일:
1077-28-7.mol
MSDS 파일:
SDS

DL-6,8-티옥트 산 속성

녹는점
60-62 °C
끓는 점
160-165 °C(lit.)
밀도
1.2888 (rough estimate)
굴절률
1.5200 (estimate)
인화점
160-165°C
저장 조건
2-8°C
용해도
에탄올: 50mg/mL
물리적 상태
결정 또는 결정성 분말
산도 계수 (pKa)
4.75±0.10(Predicted)
색상
노란색
수용성
0.9g/L(20℃)
Merck
14,9326
BRN
81853
안정성
안정적인. 강한 산화제와 호환되지 않습니다.
InChIKey
AGBQKNBQESQNJD-UHFFFAOYSA-N
LogP
2.530 (est)
CAS 데이터베이스
1077-28-7(CAS DataBase Reference)
NIST
Dl-thioctic acid(1077-28-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-20/21/22
안전지침서 37/39-26-24/25-36-36/37/39
WGK 독일 3
RTECS 번호 JP1192000
HS 번호 29349990
유해 물질 데이터 1077-28-7(Hazardous Substances Data)
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
1
2 0

DL-6,8-티옥트 산 MSDS


5-(Dithiolan-3-yl)valeric acid

DL-6,8-티옥트 산 C화학적 특성, 용도, 생산

개요

DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant. DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.

화학적 성질

Light-Yellow Solid

용도

(±)-α-Lipoic acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay. It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period.

일반 설명

Oxidized form. Has antioxidant properties. Growth factor for many bacteria and protozoa.

Pharmaceutical Applications

Lipoic acid(ALA), also known as α-lipoic acid (alpha-lipoic acid) or thioctic acid, has the formula C8H14S2O2 and systematic name 5-(1,2-dithiolan-3-yl)pentanoic acid. It contains a disulfide group, which can be transformed in the body to a dithiol group.
ALA has been on the market since the 1950s as a dietary supplement. It is a natural antioxidant usually made by the body. The advantage of ALA over other antioxidants such as vitamin C and E is that it is soluble both in water and in fat. Researchers in the former Soviet Union found that ALA can chelate mercury once it is transformed into the dithiol-containing compound. ALA can penetrate both the blood–brain barrier and the cell membrane and therefore would be a very interesting chelating agent. Nevertheless, there is much debate about its mode of action, side effects and effectiveness. Other antidotes, such as BAL and DMSA, are more efficient in the removal of heavy metals. ALA has not received FDA approval as a chelating agent, but it is still sold as a food supplement.

Purification Methods

It forms yellow needles from cyclohexane or hexane and has been distilled at high vacuum; and sublimes at ~90o and very high vacuum. It is insoluble in H2O but dissolves in alkaline solution. [Lewis & Raphael J Chem Soc 4263 1962, Soper et al. J Am Chem Soc 76 4109, Reed & Niu J Am Chem Soc 77 416 1955, Tsuji et al. J Org Chem 43 3606 1978, Calvin Fed Proc USA 13 703 1954.] The S-benzylisothiuronium salt has m 153-154o (evacuated capillary, from MeOH), 132-134o, 135-137o (from EtOH). The dand lforms have m 45-47.5o and [] D 23 ±113o (c 1.88, *C6H6) and have UV in MeOH with max at 330nm ( 140). [Beilstein 19/7 V 237.] The reduced form, (±)-6,8-dimercaptooctanoic acid, [7516-48-5] M 208.3, is a light yellow liquid which is sold in sealed ampoules.

DL-6,8-티옥트 산 준비 용품 및 원자재

원자재

준비 용품


DL-6,8-티옥트 산 공급 업체

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