Lomerizine hydrochloride
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Lomerizine hydrochloride 속성
- 녹는점
- 214-218°C dec.
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- DMSO: ≥30mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황갈색까지
- Merck
- 14,5563
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 101477-54-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,N | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-50 | ||
| 안전지침서 | 61 | ||
| 유엔번호(UN No.) | UN 3077 9 / PGIII | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | TK9189000 | ||
| HS 번호 | 29335990 | ||
| 독성 | LD50 orally in mice: 300 mg/kg (Ohtaka) |
Lomerizine hydrochloride C화학적 특성, 용도, 생산
개요
Lomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination of mechanisms, especially a functional block of L-type voltagesensitive calcium channels (L-VSCCs). Lomerizine increases cerebral blood flow compared to peripheral blood flow with only weak effects on systemic arterial blood pressure. Other mechanisms involved could be blockade of other VSCC and sodium channels, 5-HT2 and alpha-1 receptors. As a reducing agent of cortical spreading depression and neurogenic inflammation, Lomerizine was shown to be useful in migraine. In an open clinical study, it demonstrated efficacy in the treatment of cluster headache. Moreover, it may have utility in other neurological diseases such as cerebrovascular ischemia or cerebral infarction.화학적 성질
Colourless Crystalline Solid용도
A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.Lomerizine hydrochloride 준비 용품 및 원자재
원자재
Spirit of ether
Trimetazidine
1-CHLOROMETHYL-2,3,4-TRIMETHOXYBENZENE
4,4'-Difluorodiphenylmethylchloride
4,4'-Difluorobenzhydrylpiperazine
2,3,4-Trimethoxybenzaldehyde
준비 용품
Lomerizine hydrochloride 공급 업체
글로벌( 211)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1320 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 |
sean.lv@synzest.com | China | 323 | 58 |
| SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
| SINOPRO.CO.LTD | 0082-42-721-7177 |
michael@sinopro.co.kr | South Korea | 298 | 58 |
Lomerizine hydrochloride 관련 검색:
피페라진 디하이드로클로라이드 1-(2,3,4-트리메톡시벤질)피페라진 디하이드로클로라이드
4,4'-Difluorobenzhydrylpiperazine
(S)-1-(4-FLUOROPHENYL)ETHYLAMINE
Lomerizine hydrochloride
Lomerizine
(R)-1-(4-Fluorophenyl)ethylamine
(R)-1-(4-Fluorophenyl)ethylamine hydrochloride
Belarizine
1-(4-FLUORO-BENZYL)-PIPERAZINE 2HCL
1-(3,4-DIMETHOXY-BENZYL)-PIPERAZINE
1-(4-METHOXY-BENZYL)-PIPERAZINE DIHYDROCHLORIDE
(S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE
(R)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE
1-[1-(4-FLUORO-PHENYL)-ETHYL]-PIPERAZINE
C-(4-FLUORO-PHENYL)-C-PHENYL-METHYLAMINE HYDROCHLORIDE
1-(4-FLUORO-ALPHA-PHENYLBENZYL)PIPERAZINE
(4-fluorophenyl)(phenyl)methylamine