2-Tolylboronic acid
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2-Tolylboronic acid 속성
- 녹는점
- 162-164 °C(lit.)
- 끓는 점
- 283.4±33.0 °C(Predicted)
- 밀도
- 1.10±0.1 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 8.61±0.58(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 베이지색
- 수용성
- 물에 약간 용해됩니다.
- BRN
- 2935796
- InChI
- InChI=1S/C7H9BO2/c1-6-4-2-3-5-7(6)8(9)10/h2-5,9-10H,1H3
- InChIKey
- NSJVYHOPHZMZPN-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC=C1C)(O)O
- CAS 데이터베이스
- 16419-60-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36-37/39 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | ED7777777 | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29163990 |
2-Tolylboronic acid C화학적 특성, 용도, 생산
물리적 성질
beige crystalline powder용도
suzuki reactionSynthesis
Triphenylphosphene (0.131 g, 0.5 mmol, 20 mol %), p-iodoanisol (0.585 g, 2.5 mmol), and triethylamine (1.78 mL, 12.5 mmol) were added to a 50 mL round-bottomed flask equipped with a sidearm, condenser, and stir bar. This solution was then degassed by alternating vacuum and argon three times. Palladium dichloride (0.023 g, 0.13 mmol, 5 mol %) was then added under positive argon pressure. After stirring at room temperature for 15 min, diisopropylaminoborane (5 mL, 1 M solution in THF, 5 mmol) was added and the reaction mixture was degassed again by alternating vacuum and argon three times. The reaction solution was then heated to reflux. After 12 h of reflux the reaction was cooled to 0 °C and 6 mL of methanol was added through the condenser slowly (Caution: exothermic reaction with evolution of hydrogen). After 15 min of stirring all the solvent was removed under reduced pressure to yield a black solid. This solid was dissolved with sodium hydroxide (3 M, 8 mL) and subsequently washed with hexanes (3×10 mL). The aqueous layer was then cooled to 0 °C (ice bath) and acidified to pH ≤1 with concentrated HCl, with the boronic acid usually precipitating out as a white solid. The aqueous fraction was then extracted with diethyl ether (3×10 mL). The organic fractions were combined, dried with magnesium sulfate and filtered. The solvent was then removed under reduced pressure yielding a white solid named 2-Tolylboronic acid.2-Tolylboronic acid 준비 용품 및 원자재
원자재
브롬화옥틸
boranylbis(propan-2-yl)amine
요오드톨루엔
TRIBUTYL(2-METHYLPHENYL)STANNANE
O-TOLYLMAGNESIUM BROMIDE
2-METHYLPHENYLBORONIC ACID, PINACOL ESTER
TETRAHYDROXYDIBORON
o-Tolyl Trifluoromethanesulfonate
tert-부틸리튬
O-톨루이딘
o-브로모톨루엔
준비 용품
2-Tolylboronic acid 공급 업체
글로벌( 446)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 |
18522618860@163.com | China | 694 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 |
sales@toref-standards.com | China | 1000 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |