ChemicalBook >제품 카탈로그 >유기 화학>아미드>술폰산 아미노 화합물>[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate 구조식 이미지

카스 번호:: 150080-09-4

상품명:: [(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate

동의어(영문):: CS-1219;PT100 mesylate;Unii-V8zg4Y1B51;Talabostat Mesilate;Talabostat mesylate;Val-boroPro mesylate;Adrafinil Impurity 6;Talabostat-mesylate, PT-100;[(2R)-1-(L-Valyl)-2-pyrrolidinyl]boronic acid methanesulfonate (1:1);[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate

CBNumber:: CB52128758

분자식:: C10H23BN2O6S

포뮬러 무게:: 310.17

MOL 파일:: 150080-09-4.mol

속성

안전

용도

공급 업체 105

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate 속성

녹는점: >160°C (dec.)

저장 조건: under inert gas (nitrogen or Argon) at 2–8 °C

용해도: DMSO에 용해됨(최대 25mg/ml)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 하얀색

안정성: 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.

안전

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate C화학적 특성, 용도, 생산

개요

Talabostat is a non-selective inhibitor of dipeptidyl peptidases (DPPs), including DPP-4, DPP-7, DPP-8, DPP-9, fibroblast activation protein (FAP), and prolyl endopeptidase (PREP; IC₅₀s = >4, 310, 4, 11, 560, and 390 nM, respectively). It inhibits proliferation of superantigen-stimulated human peripheral blood mononuclear cells (PBMCs; IC₅₀ = ~10 nM). Talabostat (5 μg twice per day) increases expression of a variety of cytokines, including those encoding IL-1β, IL-6, and G-CSF, and chemokines in tumors and tumor-draining lymph nodes in a WEHI-164 fibrosarcoma mouse model. It reduces tumor growth in WEHI-164, MM45T.Sp, and MM52.T fibrosarcoma, EL-4 and A20/2J lymphoma, B16/F10 melanoma, and P815 mastocytoma syngeneic mouse models. Talabostat also increases the efficacy of the antitumor antibodies rituximab and trastuzumab in Namalwa B cell lymphoma and LS180 colon carcinoma mouse xenograft models, respectively.

용도

Treatment of cancer; hematopoetic stimulant.

Biochem/physiol Actions

Cell permeable: yes

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate 준비 용품 및 원자재

원자재

준비 용품

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate 공급 업체

글로벌( 105)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	sales@alabiochem.com	China	884	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29798	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49392	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29822	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14350	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	23899	58

[(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate 관련 검색:

글리신 메탄술폰산 6-아미노 카프로산 트리플루오로메탄술폰산 트리스(하이드록시메틸)아미노메탄 Pefloxacin mesylate Imatinib ALTRENOGEST Pazufloxacin mesilate AMPRENAVIR Masitinib Tamsulosin hydrochloride Orlistat Bendamustine hydrochloride Phentolamine mesilate Levofloxacin Methylate AMINO ACIDS [(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate