LOPRAZOLAM C화학적 특성, 용도, 생산
Originator
Avlane,J.A.S.M.,France,1981
Manufacturing Process
1.1 g of methanesulfonic acid were added dropwise to a mixture of 4.6 g of 8-
nitro-1,2-dihydro-2-(N-methylpiperazin-1-yl)methylene-6-(o-chlorophenyl)-
1H,4H-imidazo-[1,2-a][1,4]benzodiazepin-1-one in 100 ml of anhydrous
methylene chloride and 5 ml of methanol. Dry ether was slowly added until
crystals formed on scratching and the solution was allowed to crystallize with
further ether being added to complete the crystallization. The pale yellow solid
was filtered off, washed with ether and crystallized from methylene chloridemethanol to obtain 5.4 g of 8-nitro-1,2-dihydro-2-(N-methylpiperazin-1-
yl)methylene-6-(o-chlorophenyl)-1H,4H-imidazo-[1,2-a][1,4]-benzodiazepin-1-
one methanesulfonate melting at 205°C to 210°C.
Therapeutic Function
Tranquilizer
LOPRAZOLAM 준비 용품 및 원자재
원자재
준비 용품
