K 579;Dipeptidyl Peptidase IV Inhibitor IV;Dipeptidylpeptidase IV Inhibitor IV, K579;Dipeptidylpeptidase IV Inhibitor IV, K579 - CAS 440100-64-1 - Calbiochem;(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile;(2S)-1-[2-[(4-methyl-1-pyrimidin-2-yl-4-piperidyl)amino]acetyl]pyrrolidine-2-carbonitrile;(2S)-1-[[[4-METHYL-1-(2-PYRIMIDINYL)-4-PIPERIDINYL]AMINO]ACETYL]-2-PYRROLIDINECARBONITRILE;2-Pyrrolidinecarbonitrile, 1-[2-[[4-methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-, (2S)-
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
물리적 상태
고체
물리적 상태
단단한 모양
안전
WGK 독일
3
(2S)-1-[[[4-METHYL-1-(2-PYRIMIDINYL)-4-PIPERIDINYL]AMINO]ACETYL]-2-PYRROLIDINECARBONITRILE C화학적 특성, 용도, 생산
용도
K 579 is a slow-binding inhibitor of dipeptidyl peptidase IV and a long-acting hypoglycemic agent.
일반 설명
Dipeptidyl Peptidase IV Inhibitor IV, also known as K579 ((S)-1-[4-methyl-1-(2-pyrimidinyl)-4-piperidylamino]acetyl-2-pyrrolidinecarbonitrile), is orally available. It has a formula weight of 339.39 g/mol.
생물학적 활성
Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC 50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.
(2S)-1-[[[4-METHYL-1-(2-PYRIMIDINYL)-4-PIPERIDINYL]AMINO]ACETYL]-2-PYRROLIDINECARBONITRILE 준비 용품 및 원자재
원자재
준비 용품
(2S)-1-[[[4-METHYL-1-(2-PYRIMIDINYL)-4-PIPERIDINYL]AMINO]ACETYL]-2-PYRROLIDINECARBONITRILE 공급 업체
