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MK-0822

MK-0822 구조식 이미지
카스 번호:
603139-19-1
상품명:
MK-0822
동의어(영문):
MK-0822;ODANACATIB;Unii-N673F6W2vh;Odanacatib, >=98%;Odanacatib(Mk0822);(MK0822,Odanacatib);Odanacatib,MK-0822,MK0822;N-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucinamide;(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide;(2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
CBNumber:
CB52455399
분자식:
C25H27F4N3O3S
포뮬러 무게:
525.564
MOL 파일:
603139-19-1.mol

MK-0822 속성

밀도
1.35

안전

MK-0822 C화학적 특성, 용도, 생산

효소 저해제

This investigational osteoporosis/bone-metastasis drug (FW = 525.56 g/mol; CAS 603139-19-1), also known by the code name MK-0822 and its systematic name N-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro- 1-[4'-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucinamide, targets the cathepsin K, a unique collagenolytic lysosomal cysteine protease that is secreted, thereby facilitating bone resorption by cleaving type-1 collagen under acidic pH. Cathepsin K exhibits a unique cleavage pattern of type I collagen molecules that is fundamentally different from that of other endogenous collagenases. Women receiving ODN (10-50 mg) for 5 years had gains in spine and hip bone mineral density (BMD), showing larger reductions in bone resorption than bone formation markers. Significantly, discontinuation of ODN resulted in reversal of treatment effects. An odanacatib synthesis, which describes a novel stereospecific SN2 triflate displacement of a chiral a-trifluoromethylbenzyl triflate with (S)-g-fluoroleucine ethyl ester, achieves a 61% overall yield in 6 steps.

MK-0822 준비 용품 및 원자재

원자재

준비 용품


MK-0822 공급 업체

글로벌( 94)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Alpha Biopharmaceuticals Co., Ltd
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Nanjing ChemLin Chemical Industry Co., Ltd.
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career henan chemical co
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Biochempartner
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Hubei xin bonus chemical co. LTD
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BOC Sciences
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Chongqing Chemdad Co., Ltd +86-13650506873
sales@chemdad.com CHINA 30864 58
WuYan Pharmaceutical Technology (Shanghai) Co., Ltd. 0512-53995837,13371908063
021-61114075 sales@wuyanpharm.com China 63 55
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2926 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

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