1-(4-플루오로페닐카르바모일)시클로프로판카르복실산
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1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 속성
- 녹는점
- 173.0 to 177.0 °C
- 끓는 점
- 475.2±30.0 °C(Predicted)
- 밀도
- 1.521
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 메탄올에 용해됨
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 3.48±0.20(Predicted)
- 색상
- 흰색에서 거의 흰색
- InChI
- InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)
- InChIKey
- PFMAFXYUHZDKPY-UHFFFAOYSA-N
- SMILES
- C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1
안전
- 위험 및 안전 성명
HS 번호 | 2924.29.9500 |
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1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 C화학적 특성, 용도, 생산
화학적 성질
White powdery substance.용도
1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.Synthesis
Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 준비 용품 및 원자재
원자재
1,1-사이클로프로판디카보닐디클로라이드(9CI)
시클로프로판카르복실산,1-(클로로카르보닐)-(9CI)
메틸1-[(4-플루오로페닐)카르바모일]시클로프로판카르복실레이트
에틸1-((4-플루오로페닐)카르바모일)시클로프로판카르복실레이트
1-(에톡시카르보닐)시클로프로판카르복실산
1,1-사이클로프로판디카르복실산모노메틸에스테르
1,1-Cyclopropanedicarboxylic acid dimethyl ester
플로로아닐린
1,1-Cyclopropanedicarboxylic acid
4-플로로아닐린
Diethyl 1,1-cyclopropanedicarboxylate
준비 용품
1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 공급 업체
글로벌( 250)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Huanfu Industrial Co.,(Shanghai)Ltd. | +86-18001856580 +86-18001856580 |
2415195517@qq.com | China | 43 | 58 |
Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 |
admin@hblongbang.com | China | 942 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20292 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1009 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 931 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Shandonghaohong biotechnology Co.,ltd. | 0635-6175299 13961496334 |
sale@inyelchem.com | CHINA | 44 | 55 |
1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 관련 검색:
2-Aminocyclohexanone
4-Aminodiphenylamine
4-Benzothiazolamine (9CI)
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Cabozantinib Malate
4-Aminoveratrole
Cabozantinib Impurity 5
N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
4-chloro-6,7-dimethoxyquinoline
Cabozantinib Impurity EXA
Cabozantinib impurity DX2
Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]-
1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl-
Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)-
Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]-
1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-
Cabozantinib impurity 1DYH
Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]-