ChemicalBook >제품 카탈로그 >제약 중간체>벌크 의약품 중간체>5-Methyl-3,4-diphenylisoxazole

5-Methyl-3,4-diphenylisoxazole

5-Methyl-3,4-diphenylisoxazole 구조식 이미지

카스 번호:: 37928-17-9

상품명:: 5-Methyl-3,4-diphenylisoxazole

동의어(영문):: 5-Methyl-3;CAS:37928-17-9;Parecoxib Sodium-4;5-Methyl-3,4-diphenyl;Parecoxib Related Compound;5-Methyl-3,4-diphenylisoxazole;3,4-Diphenyl-5-methylisoxazole;Parecoxib SodiuM iMpurity PR-SM;Parecoxib SodiuM interMediate A;Isoxazole, 5-Methyl-3,4-diphenyl-

CBNumber:: CB52604537

분자식:: C16H13NO

포뮬러 무게:: 235.28

MOL 파일:: 37928-17-9.mol

속성

안전

용도

공급 업체 299

5-Methyl-3,4-diphenylisoxazole 속성

녹는점: 96.0 to 100.0 °C

끓는 점: 340.1±21.0 °C(Predicted)

밀도: 1.108±0.06 g/cm3(Predicted)

저장 조건: Sealed in dry,Room Temperature

용해도: 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): -2.53±0.50(Predicted)

색상: 흰색에서 황백색까지

InChIKey: ZXIRUKJWLADSJS-UHFFFAOYSA-N

안전

위험 및 안전 성명

HS 번호	2934.99.4400

그림문자(GHS):

신호 어:

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드

예방조치문구:

NFPA 704

	1
2		0

5-Methyl-3,4-diphenylisoxazole C화학적 특성, 용도, 생산

용도

5-Methyl-3,4-diphenylisoxazole is synthesis The key intermediate of Parecoxib Sodium (Parecoxib Sodium).Parecoxib Sodium is by the Pfizer of the U.S. The cox 2 inhibitor of company's research and development, listed in European Union in 2002, trade name Dynastat, is used for The short term therapy of postoperative pain.

Synthesis

In four mouthfuls of round-bottomed flasks of a 1L add compound 2 (40g), methanol (400mL), 7.7% Aqueous sodium carbonate (400mL), is heated to 70 DEG C, after stirring reaction 2h, and TLC plate monitoring raw material Fundamental reaction is complete, and solution is divided into solid-liquid biphase, is extracted with ethyl acetate, collected organic layer, with anhydrous Sodium sulfate is dried, and vacuum obtains white solid, HPLC purity: 94.9% after being spin-dried for.White solid uses 40ml ethyl acetate and the mixed solvent recrystallization of 120ml normal hexane (1:3) again, Obtaining target compound is white solid 34.2g, yield 92%, HPLC purity: 99.7%.m.p.97-98??￡? MS(m/z):236(M+H)+￡?1H NMR(400MHz,CDCl3) |?:2.43(s,3H,-CH3), 7.19-7.43 (m, 10H ,-CH=).

5-Methyl-3,4-diphenylisoxazole 준비 용품 및 원자재

원자재

준비 용품

Parecoxib Valdecoxib Valdecoxib IMpurity B

5-Methyl-3,4-diphenylisoxazole 공급 업체

글로벌( 299)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
ZHEJIANG ESTCHEM CO.,LTD	15957180504	sales@zjestchem.com	China	193	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55

5-Methyl-3,4-diphenylisoxazole 관련 검색:

BenzenesulfonaMide, 3-[4-[4-(aMinosulfonyl)phenyl]-5-Methyl-3-isoxazolyl]- Valdecoxib IMpurity B Parecoxib 1-Hydroxy Valdecoxib Parecoxib Impurity 18 Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole 4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)acetaMide 4-[(5-Methyl-3-phenyl-4-isoxazolyl)methyl]benzenesulfonamide 2-Phenylacetophenone 3-methyl -4,5-diphenyl-4,5-didydro-isoxazole Valdecoxib IMpurity-E Valdecoxib Deoxybenzoin Oxime 5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL Valdecoxib IMpurity D PARECOXIB SODIUM