ChemicalBook >제품 카탈로그 >하이드록시프로필메틸셀룰로오스아세테이트/석시네이트

하이드록시프로필메틸셀룰로오스아세테이트/석시네이트

하이드록시프로필메틸셀룰로오스아세테이트/석시네이트 구조식 이미지

카스 번호:: 71138-97-1

한글명:: 하이드록시프로필메틸셀룰로오스아세테이트/석시네이트

동의어(한글):: 하이드록시프로필메틸셀룰로오스아세테이트/석시네이트

상품명:: HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE

동의어(영문):: HPMCAS;HyproMellose Acetate Succinate;HPMCAS AS-MF;acetic acid, methanol;Hypromellose Acetate Succinate (100 mg);Hypromellose Acetate Succinate (1335279);Acetate hydroxypropyl methylcellulose succinate;HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE;Hydroxypropyl Methyl cellulose acetate succinate JPE;2-hydroxypropylmethylehter,acetatehydrogenbutanedioate

CBNumber:: CB5265556

분자식:: C10H22O9

포뮬러 무게:: 0

MOL 파일:: Mol file

MSDS 파일:: SDS

속성

안전

용도

공급 업체 88

하이드록시프로필메틸셀룰로오스아세테이트/석시네이트 속성

녹는점: >203°C (dec.)

저장 조건: Hygroscopic, -20°C Freezer, Under inert atmosphere

용해도: Practically insoluble in ethanol (95%), hexane, unbuffered water, and xylene. On the addition of acetone, or a mixture of ethanol (95%) and dichloromethane (1 : 1), a clear or turbid viscous solution is produced. Hypromellose acetate succinate also forms a clear or turbid solution in buffers of pH greater than 4.5 with the rank order of solubility for the various grades increasing with the ratio of acetyl over succinoyl substitution. The exact pH value at which the polymer starts to swell and dissolve depends on the buffer type and ionic strength, although the rank order for the different grades is independent of the buffer used. No solvent has been found to completely dissolve hypromellose acetate succinate polymer; the resulting clear or turbid solutions significantly scatter light in both static and dynamic light scattering experiments, indicating that the polymer may exist as colloids or aggregates. The data is collated from the Shin-Etsu Chemical Co. Ltd and the research work of the authors (R Chen, BC Hancock, and RM Shanker).

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 황백색까지

안정성: 흡습성

LogP: -0.591 (est)

안전

HS 번호	3912390000
기존화학 물질	2010-3-4896

하이드록시프로필메틸셀룰로오스아세테이트/석시네이트 C화학적 특성, 용도, 생산

화학적 성질

soluble in organic solvents, including acetone, methanol, aqueous ethanol

용도

Hypromellose Acetate Succinate HPMCAS;is a pharmaceutical compound comprising enzalutamide.

생산 방법

Hypromellose acetate succinate is produced by the esterification of hypromellose with acetic anhydride and succinic anhydride, in a reaction medium of a carboxylic acid, such as acetic acid, and using an alkali carboxylate, such as sodium acetate, as catalyst. The fibrous reaction product is precipitated out by adding a large volume of water to the reaction medium. Purification is achieved by thorough washing with water. The granular grade of hypromellose acetate succinate that is so obtained can be pulverized to a fine powder if required.

Pharmaceutical Applications

Hypromellose acetate succinate is commonly used in oral pharmaceutical formulations as a film coating, as well as an enteric coating material for tablets or granules. It is a solubility enhancing agent via solid dispersion. Hypromellose acetate succinate is insoluble in gastric fluid but will swell and dissolve rapidly in the upper intestine. For aqueous film-coating purposes, a dispersion of hypromellose acetate succinate fine powder and triethyl citrate (as a plasticizer) in water is commonly utilized. Organic solvents can also be used as vehicles for applying this polymer as a film coating.
Hypromellose acetate succinate may be used alone or in combination with other soluble or insoluble binders in the preparation of granules with sustained drug-release properties; the release rate is pH-dependent.
Dispersions of poorly soluble drugs with hypromellose acetate succinate are prepared using techniques such as mechanical grinding, solvent evaporation, and melt extrusion.

Safety

The safety and pharmacological profiles of hypromellose acetate succinate are similar to those of other ether and ester derivatives of cellulose. All nonclinical studies reported in the literature identify no target organs for toxicity by hypromellose acetate succinate. It has also been reported that hypromellose acetate succinate does not alter fertility in rats, does not produce any developmental anomalies in rats and rabbits, and does not alter perinatal and postnatal development in rats when assessed up to 2500 mg/kg body-weight

저장

Hypromellose acetate succinate should be stored in a well-closed container, in a cool, dry place. In such storage conditions, hypromellose acetate succinate is a stable material. Hypromellose acetate succinate is hygroscopic. It is hydrolyzed to acetic acid and succinic acid, and the hypromellose polymer starts to form if dissolved in 1 mol/L sodium hydroxide for more than two hours. The hydrolysis is the main degradation pathway that is responsible for increasing amounts of free acids in storage, especially upon exposure to moisture.

비 호환성

Hypromellose acetate succinate is incompatible with strong acids or bases, oxidizing agents, and sustained levels of elevated humidity.

Regulatory Status

Included in the FDA Inactive Ingredients Database for use in oral preparations (capsules, and delayed-action preparations). Hypromellose acetate succinate has been approved for use in commercial pharmaceutical products in the USA and in Japan.

하이드록시프로필메틸셀룰로오스아세테이트/석시네이트 준비 용품 및 원자재

원자재

준비 용품

하이드록시프로필메틸셀룰로오스아세테이트/석시네이트 공급 업체

글로벌( 88)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Hebei Zhanyao Biotechnology Co. Ltd	15369953316 +8615369953316	admin@zhanyaobio.com	China	2136	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5985	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58

하이드록시프로필메틸셀룰로오스아세테이트/석시네이트 관련 검색:

하이드록시프로필 메틸셀룰로스 알루미늄 아세틸아세토네이트 아세틸아세톤산 구리 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 코발트(II) 아세틸아세토네이트 하이드레이트 실버 아세틸아세토네이트 아세틸아세토산 제2철 메틸 셀룰로오스 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Ethyl isocyanoacetate PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE Benzyl isocyanide TERT-BUTYL ISOCYANIDE Tosylmethyl isocyanide