Oclacitinib
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Oclacitinib 속성
- 녹는점
- 226-228°C
- 밀도
- 1.316±0.06 g/cm3(Predicted)
- 증기압
- 0Pa at 20-25℃
- 저장 조건
- Refrigerator, Under inert atmosphere
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 초음파처리)
- 산도 계수 (pKa)
- 11.59±0.40(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 미색부터 페일 베이지까지
- InChI
- InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)/t11-,12-
- InChIKey
- HJWLJNBZVZDLAQ-HAQNSBGRSA-N
- SMILES
- [C@@H]1(CS(NC)(=O)=O)CC[C@@H](N(C)C2N=CN=C3NC=CC3=2)CC1
- LogP
- 1.38 at 35℃ and pH7
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 신호 어: | Warning | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Oclacitinib C화학적 특성, 용도, 생산
개요
Oclacitinib is an oral JAK inhibitor that is a drug approved by the U.S. Food and Drug Administration (FDA) for use in canine atopic dermatitis (AD). The U.S. FDA and the European Medical Association have approved a number of JAK inhibitors, including baricitinib, ruxolitinib, federatinib, tofacitinib, upadacitinib, oclacitinib, but some of these drugs are still being studied. Oclacitinib mainly shows activity against JAK1-dependent cytokines and also inhibits the function of JAK2-dependent cytokines. oclacitinib modifies the production of cytokines such as IL-4 and IL-13, which are crucial for B-cell proliferation and maturation in the pathogenesis of pemphigus foliaceus. Oclacitinib could interdict the effects of IL-6, a cytokine involved in the Toll-like receptor 4-originated signaling pathway in the bladder epithelial cells, and IL-8, which could theoretically contribute to a decreased defense against the urinary pathogens[1-4].용도
Oclacitinib is a novel Janus kinase (JAK) inhibitor with activity against cytokines involved in allergy.Oclacitinib 준비 용품 및 원자재
원자재
준비 용품
Oclacitinib 공급 업체
글로벌( 160)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7377 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 |
yuhh@hitechem.com | CHINA | 811 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 12431 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12453 | 58 |
Oclacitinib 관련 검색:
풀 베스트 한
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PF-6274484
PF-9366
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
PF06869206
Flumethrin
Cyfluthrin
Pentoxifylline
Nilotinib
Boc-D-Glutamine
Pazopanib
Veliparib
AZD-9291
Everolimus