ChemicalBook >제품 카탈로그 >Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) 구조식 이미지
카스 번호:
1246298-62-3
상품명:
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
동의어(영문):
Kdo2-Lipid A;Kdo2-Lipid A (KLA);Kdo2-Lipid A ammonium;Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt);DI[3-DEOXY-D-MANNO-OCTULOSONYL]-LIPID A (AMMONIUM SALT);KDO2-LIPID A;Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution;O-3-Deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-4)-O-3-deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-beta-D-glucopyranosyl-(1-6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] ammonium salt (1:4)
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) 속성
저장 조건
-20°C
물리적 상태
고체
물리적 상태
단단한 모양
안전
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) C화학적 특성, 용도, 생산
용도
Kdo2-Lipid A (KLA) is a nearly homogeneous Re lipopolysaccharide (LPS) substracture with endotoxin activity equal to tha of native LPS. KLA is comparable to LPS and its activity is reduced by >10^3 in cells fro TLR-4 deficient mice.
일반 설명
3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model.
Biochem/physiol Actions
Kdo2-Lipid A might be useful to stimulate inflammatory response.
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) 준비 용품 및 원자재
원자재
준비 용품
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) 공급 업체
