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EPZ011969

EPZ011969 구조식 이미지

카스 번호:: 1598383-40-4

상품명:: EPZ011969

동의어(영문):: CS-1609;CS-2079;EPZ011989;EPZ011969;EPZ011989;EPZ-011989;EPZ011989,inhibit,Histone Methyltransferase,Inhibitor,EPZ 011989,EPZ-011989;N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-ynyl)benzamide;N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-(ETHYL((TRANS)-4-((2-METHOXYETHYL)(METHYL)AMINO)CYCLOHEXYL)AMINO)-2-METHYL-5-(3-MORPHOLINOPROP-1-YN-1-YL)BENZAMIDE;N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]benzamide;Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-

CBNumber:: CB52741562

분자식:: C35H51N5O4

포뮬러 무게:: 605.81

MOL 파일:: 1598383-40-4.mol

속성

안전

용도

공급 업체 75

EPZ011969 속성

끓는 점: 756.7±60.0 °C(Predicted)

밀도: 1.17±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO:55.0(Max Conc. mg/mL);90.79(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);16.51(Max Conc. mM)
Ethanol:60.0(Max Conc. mg/mL);99.04(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.83(Max Conc. mM)

물리적 상태: 결정성 고체

산도 계수 (pKa): 11.88±0.10(Predicted)

안전

EPZ011969 C화학적 특성, 용도, 생산

개요

The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EPZ011989 is an orally bioavailable EZH2 inhibitor with K_i values that are less than 3 nM for wild type and Tyr⁶⁴⁶ mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

용도

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]-benzamide is used in biological studies as inhibitors of EZH2 histone methyltransferase for the treatment of cancer.

EPZ011969 준비 용품 및 원자재

원자재

준비 용품

EPZ011969 공급 업체

글로벌( 75)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1472	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58