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tert-Butyl 3-oxoazetidine-1-carboxylate

tert-Butyl 3-oxoazetidine-1-carboxylate 구조식 이미지

카스 번호:: 398489-26-4

상품명:: tert-Butyl 3-oxoazetidine-1-carboxylate

동의어(영문):: 1-BOC-3-AZETIDINONE;N-Boc-3-azetidinone;N-Boc-Azetidin-3-one;3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 3-Ox;Baricitinib-011;1-Boc azitidone;N-boc-3-azetidine;1-Boc-3-azetidione;1-Boc-3-acetidinone

CBNumber:: CB5282384

분자식:: C8H13NO3

포뮬러 무게:: 171.19

MOL 파일:: 398489-26-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 485

tert-Butyl 3-oxoazetidine-1-carboxylate 속성

녹는점: 47-51 °C

끓는 점: 251.3±33.0 °C(Predicted)

밀도: 1.174±0.06 g/cm3(Predicted)

인화점: 102 °C

저장 조건: Inert atmosphere,2-8°C

용해도: 클로로포름(소량으로 용해), 디클로로메탄(약간 용해됨)

산도 계수 (pKa): -1.99±0.20(Predicted)

물리적 상태: 결정성 분말

색상: 흰색에서 황백색까지

감도: Moisture Sensitive/Stench

InChI: InChI=1S/C8H13NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h4-5H2,1-3H3

InChIKey: VMKIXWAFFVLJCK-UHFFFAOYSA-N

SMILES: N1(C(OC(C)(C)C)=O)CC(=O)C1

CAS 데이터베이스: 398489-26-4(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi,Xn
위험 카페고리 넘버	22-37/38-41
안전지침서	26-39
유엔번호(UN No.)	UN 3335
WGK 독일	3
위험 등급	IRRITANT
HS 번호	29339900

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H318	눈에 심한 손상을 일으킴	심한 눈 손상 또는 자극성 물질	구분 1	위험	P280, P305+P351+P338, P310
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.

NFPA 704

	1
2		0

tert-Butyl 3-oxoazetidine-1-carboxylate C화학적 특성, 용도, 생산

화학적 성질

White to light brown solid

용도

1-Boc-3-azetidinone can be used for the preparation of antibacterial aminoglycoside analogs.

용도

tert-Butyl 3-oxoazetidine-1-carboxylate(1-Boc-3-azetidinone) is a currently common organic intermediate. It is a key intermediate for preparing various medicaments. It can be used for preparing Janus kinase 3(JAKS), which is a useful target for immunosuppression and transplant rejection, and can be used for treating inflammatory disorders, autoimmune disorders, cancer and other diseases; also useful in the preparation of a second class of HCV protease inhibitors useful in the treatment of HCV genotype 1 infection; can also be used for preparing novel aminoglycoside compounds with antibacterial activity; bicyclic himbacine (himbacine) derivatives can be prepared which are useful as antagonists of the protease activated receptor-1 (PAR-1) and are predicted to be cannabis (CB2) receptor inhibitors, useful for the treatment of secondary prevention of Acute Coronary Syndrome (ACS), myocardial infarction or thrombotic stroke or peripheral arterial disease; bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, can be prepared that modulate the activity of phospho-inositol 3-kinase (P13K) and are useful in the treatment of diseases associated with P13K, including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

tert-Butyl 3-oxoazetidine-1-carboxylate 준비 용품 및 원자재

원자재

준비 용품

1-Boc-3-iodoazetidine 3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine 1-Azetidinecarboxylicacid,3-ethyl-3-hydroxy-,1,1-dimethylethylester(9CI) tert-Butyl 3-hydroxy-3-(2-methoxyphenyl)azetidine-1-carboxylate 2-tert-Butyl 8-methyl 5-thia-2-azaspiro[3.4]octane-2,8-dicarboxylate 5,5-dioxide 3-(trifluoroMethyl)azetidin-3-olHCL tert-butyl 3-(2-tosylhydrazono)azetidine-1-carboxylate tert-butyl 3-(hydroxyimino)azetidine-1-carboxylate 3-(5-broMo-2,3-dihydro-indol-1-yl)-azetidine-1-carboxylic acid tert-butyl ester 1-BOC-3-[(2-HYDROXYETHYL)AMINO]-AZETIDINE 1-(TERT-BUTOXYCARBONYL)-3-(DIMETHYLAMINO)AZETIDINE 3-HYDROXY-3-PHENYLAZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

tert-Butyl 3-oxoazetidine-1-carboxylate 공급 업체

글로벌( 485)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Jinli Pharmaceutical Co.,Ltd	+86-21-57256005 +86-15921811235	chang@shjlchem.com	China	20	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Lianhe Aigen Pharmatech Co.,Ltd.	+86-18918657159 +86-18918657159	sales-Aigen@lianhetech.com	China	305	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
AB PharmaTech,LLC	323-480-4688		United States	989	55

tert-Butyl 3-oxoazetidine-1-carboxylate 관련 검색:

tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate N-BOC-3-AZA-HEPTAN-1-ONE 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate tert-Butyl (4-methylpiperidin-4-yl)carbamate tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate Theanine (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Methyl 8-azabicyclo[3.2.1... (R)-2-Aminomethyl-4-boc-morpholine (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)-pyrrolidine-1-carboxylate tert-Butyl 3-phenyl-L-alaninate hydrochloride tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Cyclobutanone TERT-BUTYL 2-OXOAZETIDINE-1-CARBOXYLATE 3-AZETIDINONE