Loratadine
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Loratadine 속성
- 녹는점
- 134-136°C
- 끓는 점
- 531.3±50.0 °C(Predicted)
- 밀도
- 1.261±0.06 g/cm3(Predicted)
- RTECS 번호
- TM6129200
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 26mg/mL, 용해성
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.27±0.20(Predicted)
- 색상
- 하얀색
- 수용성
- 이는 DMSO(50mg/ml), 에탄올(25°C에서 77mg/ml), 물(25°C에서 <1mg/ml), 클로로포름 및 메탄올에 용해됩니다.
- Merck
- 14,5578
- BCS Class
- 2
- 안정성
- 안정적이지만 열에 민감할 수 있습니다. 냉장 보관하세요. 강한 산화제와 호환되지 않습니다.
- InChIKey
- JCCNYMKQOSZNPW-UHFFFAOYSA-N
- CAS 데이터베이스
- 79794-75-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 22-24/25-36-26 | ||
유엔번호(UN No.) | 3077 | ||
WGK 독일 | 2 | ||
HS 번호 | 29333990 | ||
유해 물질 데이터 | 79794-75-5(Hazardous Substances Data) |
Loratadine MSDS
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
Loratadine C화학적 특성, 용도, 생산
개요
Loratadine is a non-sedating antihistamine indicated for use in allergic rhinitis and chronic urticaria. Its major advantage over other non-sedating antihistamines such as astemizole and terfenadine is its very fast onset of action. Loratadine is claimed not to cross the blood-brain barrier.화학적 성질
White Crystalline Solid용도
Loratadine, is used as a peripheral histamine H1 receptor agonist. It is also used as an orally active antiallergic agent. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.Indications
Loratadine (Claritin) is a long-acting, potent peripheral H1 blocker with minimal sedative effects. It does not appear to have the same adverse cardiac effects as the other nonsedating H1 antihistamines. It is indicated for allergic rhinitis and chronic urticaria.일반 설명
Loratadine, 4-(8-chloro-5,6-dihydro-11Hbenzo[5,6]-cyclohepta[1,2-b]pyridin-l 1-ylidene-1-carboxylic acid ethyl ester, is a white to off-white powder insoluble in water but very soluble in acetone, alcohols, and chloroform. Loratadine is structurally related to the antihistamines azatadine and cyproheptadine, and to some tricyclic antidepressants. It differs from azatadine, in that a neutral carbamate group has replaced the basic tertiary amino moiety, and a phenyl ring has been substituted with a chlorine atom. Loratadine is a selective peripheral H1-antihistamine with a receptor-binding profile like that of the other members of this series, except that it has more antiserotonergic activity. Thus, it produces no substantial CNS or autonomic side effects or cardiac toxicity.Loratadine displays potency comparable with that of astemizole and greater than that of terfenadine. Loratadine is indicated for the relief of nasal and nonnasal symptoms of seasonal allergic rhinitis. In the presence of a CYP3A4 inhibitor ketoconazole, loratadine is metabolized to descarboethoxyloratadine predominantly by CYP2D6.
생물학적 활성
Peripheral histamine H 1 receptor antagonist (K i = 35 nM); devoid of central effects. Orally active antiallergic agent.Clinical Use
Loratadine is related to the first-generation tricyclic antihistamines and to antidepressants. It is nonsedating, and neither it nor its major metabolite, desloratadine (descarboethoxyloratadine), is associated with the potentially cardiotoxic effects reported for terfenadine and astemizole. On chronic dosing, the AUC (plasma concentration–time curve) for the metabolite is greater than that for the parent drug, and its half-life is longer.Loratadine 준비 용품 및 원자재
원자재
클로로포름산에틸
피리딘
N-Methyl Desloratadine
염화티탄(Ⅳ)
테트라하이드로푸란
8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one
N-Carbethoxy-4-piperidone
준비 용품
Loratadine 공급 업체
글로벌( 807)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
APOLLO HEALTHCARE RESOURCES | +6596580999 |
sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 |
admin@zhanyaobio.com | China | 2136 | 58 |
Shenzhen Monkono Technology Co.,Ltd | +86-17063441314 |
sansbiotech@outlook.com | China | 677 | 58 |
Chengdu Aupone Pharmaceutical Co.Ltd. | +86-28-+86-28-87843998-6060-6060 +8618631098571 |
lijiaqi@aupone.com | China | 43 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |