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p38 MAP Kinase Inhibitor III

p38 MAP Kinase Inhibitor III 구조식 이미지

카스 번호:: 581098-48-8

상품명:: p38 MAP Kinase Inhibitor III

동의어(영문):: (S)-p38 MAPK Inhibitor III;(S)-p38 MAP Kinase Inhibitor III;p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem;(S)-p-38 MAPK Inhibitor III,(S) p38 MAPK Inhibitor III,(S)p38 MAPK Inhibitor III;4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine;2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-

CBNumber:: CB53136792

분자식:: C23H21FN4S

포뮬러 무게:: 404.5

MOL 파일:: 581098-48-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 11

p38 MAP Kinase Inhibitor III 속성

녹는점: 117-119 °C

끓는 점: 589.4±60.0 °C(Predicted)

밀도: 1.30±0.1 g/cm3(Predicted)

저장 조건: +2C to +8C

용해도: DMF: 20 mg/mL; DMSO: 12 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL

물리적 상태: 노란색 고체

산도 계수 (pKa): 9.07±0.10(Predicted)

안전

p38 MAP Kinase Inhibitor III C화학적 특성, 용도, 생산

개요

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC₅₀s = 0.37 and 0.044 μM, respectively).

일반 설명

A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC₅₀ = 0.38 μM for p38α). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC₅₀ = 0.16 and 0.039 μM for TNF-α and IL-1β release, respectively, in human PBMC) and in vivo (ED₅₀ = 1.33 mg/kg for TNF-α release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. A 10 mM (1 mg/247 μl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506148) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

p38 MAP Kinase Inhibitor III 준비 용품 및 원자재

원자재

준비 용품

p38 MAP Kinase Inhibitor III 공급 업체

글로벌( 11)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Nantong Hanfang Biotechnology Co. , Ltd.	3674309880	hanfangpharma@126.com	China	30968	58