티오살리실산
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티오살리실산 속성
- 녹는점
- 162-165 °C (lit.)
- 끓는 점
- 247.55°C (rough estimate)
- 밀도
- 1.49
- 굴절률
- 1.5100 (estimate)
- 인화점
- 150 °C
- 저장 조건
- Store below +30°C.
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- pK1:4.05(0) (20°C)
- 물리적 상태
- 미세 결정성 분말
- 색상
- 흰색에서 노란색으로
- 수용성
- 뜨거운 물에 용해됨
- 감도
- Air & Light Sensitive
- Merck
- 14,9360
- BRN
- 508507
- InChIKey
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N
- LogP
- 2.390
- CAS 데이터베이스
- 147-93-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn,N | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-20/21/22 | ||
안전지침서 | 26-36/37/39-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DH3325000 | ||
F 고인화성물질 | 9-23 | ||
TSCA | Yes | ||
HS 번호 | 29309070 | ||
유해 물질 데이터 | 147-93-3(Hazardous Substances Data) | ||
독성 | mouse,LD50,intraperitoneal,50mg/kg (50mg/kg),National Technical Information Service. Vol. AD277-689, | ||
기존화학 물질 | KE-23092 |
티오살리실산 C화학적 특성, 용도, 생산
화학적 성질
Thiosalicylic acid, (o-mercapto benzoic acid), a sulfur-yellow solid that softens at 158 °C (316 °F), has a melting point of 164 °C (327 °F). It sublimes, is slightly soluble in hot water but freely soluble in glacial acetic acid and alcohol, and yields dithiosalicylic acid, upon exposure to air.용도
Thiosalicylic acid acts as a trapping agent, which is useful in the desulfenylation of 3-indolyl sulfides. It is used to prepare macrocyclic diamides by condensation with diamines. Further, it is used as a precursor to drug, which finds application for the treatment of atherosclerosis and melanoma. In addition to this, it is involved in the preparation of vaccine preservative thiomersal and thioindigo dyestuff.제조 방법
Thiosalicylic acid can be prepared from anthranilic acid via diazotization followed by the addition of sodium sulfide and then reduction with zinc. It can also prepared by heating o-halogenated benzoic acids with alkaline hydrosulfide in presence of copper.주요 응용
thiosalicylic acid can be used as:A nucleophilic trapping agent for the desulfenylation of 3-indolyl sulfides to obtain 3-unsubstituted indoles.
A starting material to prepare 2′-mercaptoacetophenone, which is used in the synthesis of thioflavanone by reacting with lithium diisopropylamide and benzaldehyde.
A stabilizing agent in the synthesis of metal nanoparticles.
It can also be used to prepare 2-thioxanthone-thioacetic acid bimolecular system, which is used as a photoinitiator for free radical polymerization.
정의
ChEBI: Thiosalicylic acid is a sulfanylbenzoic acid that is the 2-sulfanyl derivative of benzoic acid. It has a role as a non-narcotic analgesic and an antipyretic. It is a conjugate acid of a thiosalicylate(1-).Purification Methods
Crystallise the thio acid from hot EtOH (4mL/g), after adding hot distilled water (8mL/g) and boiling with charcoal. The hot solution is filtered, cooled, the solid is collected and dried in vacuo (P2O5). Crystallise it from AcOH and sublime in vacuo.[Beilstein 10 IV 272.]티오살리실산 준비 용품 및 원자재
원자재
준비 용품
티아나프텐
2-(METHYLTHIO)BENZOIC ACID
2-MERCAPTOBENZYL ALCOHOL
2-클로로벤조티아졸
2-Chlorothioxanthone
티오인디고 레드 B
2-[(2-OXO-2-페닐에틸)티오]벤조산
메틸트리옥틸암모늄2-메르캅토벤조에이트
9H-Thioxanthene-2-acetic acid, 9-oxo-
2-(2-아미노에틸티오)벤조산
Benzoic acid, 2-[(4-acetylphenyl)thio]-
Benzoic acid, 2-[(2,4-dimethylphenyl)thio]-
4H-1,3-Benzothiazine-2-acetamide, 4-oxo-N-phenyl-
2-[(4-메틸벤질)술파닐]벤젠카르복실산
티오살리실산 공급 업체
글로벌( 517)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Qingdao Minzhi Yijie new material Co., LTD | +86-13589435123 +86-13589435123 |
qdmzyj@126.com | China | 240 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5866 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 988 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1009 | 58 |
Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 |
admin@hblongbang.com | China | 942 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 931 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |