테트라베나진
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테트라베나진 속성
- 녹는점
- 128-130?C
- 끓는 점
- 456.71°C (rough estimate)
- 밀도
- 1.12
- 굴절률
- 1.5180 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: >10mg/mL
- 산도 계수 (pKa)
- 6.46±0.40(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- Merck
- 14,9182
- BRN
- 40090
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 1주일 동안 보관할 수 있습니다.
- InChIKey
- MKJIEFSOBYUXJB-UHFFFAOYSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22 | ||
안전지침서 | 24/25 | ||
유엔번호(UN No.) | 3249 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DK2275000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29339900 | ||
유해 물질 데이터 | 58-46-8(Hazardous Substances Data) |
테트라베나진 C화학적 특성, 용도, 생산
화학적 성질
White to Off-White Solid용도
Tetrabenazine has been used for dopamine uptake assays in mouse brain cells1. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells2.정의
ChEBI: A benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 an 7.일반 설명
A cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.생물학적 활성
Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC 50 = 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.Purification Methods
Crystallise it from MeOH. The hydrochloride has m 208-210o, and the oxime has m 158o (from EtOH). [Beilstein 21 III/IV 6488.]테트라베나진 준비 용품 및 원자재
원자재
7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
1,2,3,4-테트라히드로이소퀴놀린
(2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide
6,7-Dimethoxy-3,4-dihydroisoquinoline
준비 용품
테트라베나진 공급 업체
글로벌( 252)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 2263 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
테트라베나진 관련 검색:
메틸(1-)-4-피페리돈
1-(3-METHOXY-PHENYL)-ETHYLAMINE
1-Phenethyl-4-piperidone
N-Methylhomoveratrylamine
1-Ethyl-4-piperidone
Salsoline
Tetrabenazine
2-Methyl-4-piperidone
1-Propyl-4-piperidone
Tetrabenazine metabolite A,Tetrabenazine metabolite B
2H-BENZO[A]QUINOLIZIN-2-ONE, 1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-, (3S,11BS)-
CHEMBRDG-BB 4014220
6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE
1-PHENYL-BUTYLAMINE
AKOS BC-3154
1-(4-METHOXY-PHENYL)-PROPYLAMINE
Isoquinoline, 1,2,3,4-tetrahydro-2-methyl-
Benzenepentanamine